PHENELZINE SULFATE Drug Interactions
Also known as: phenelzine sulfate
PHENELZINE SULFATE (brand name: phenelzine sulfate) is a MAOIs. INDICATIONS AND USAGE Phenelzine sulfate has been found to be effective in depressed patients clinically characterized as "atypical," "nonendogenous," or "neurotic." These patients often have mixed anxiety and depression and phobic or hypochondriacal features. There is less conclusive evidence of…PHENELZINE SULFATE has 3 documented drug interactions in our database, including 3 contraindicated, 0 major, 0 moderate, and 0 minor interactions.
3
Contraindicated
0
Major
0
Moderate
0
Minor
Concomitant use of sertraline and phenelzine is absolutely contraindicated due to a severe, potentially life-threatening risk of serotonin syndrome. This syndrome can manifest with mental status changes, autonomic instability, and neuromuscular abnormalities.
Mechanism
Sertraline increases serotonin levels by inhibiting its reuptake, while phenelzine, an MAOI, prevents serotonin breakdown. The combined effect leads to excessive accumulation of serotonin in the central nervous system.
Clinical Management
This combination must be avoided. A washout period of at least 14 days is required when switching from phenelzine to sertraline, and at least 14 days when switching from sertraline to phenelzine. Patients should be closely monitored for serotonin syndrome symptoms if inadvertent co-administration occurs.
The co-administration of fluoxetine and phenelzine is absolutely contraindicated due to a high risk of developing serotonin syndrome, a potentially life-threatening condition. Symptoms can include mental status changes, autonomic instability, and neuromuscular abnormalities.
Mechanism
Fluoxetine increases serotonin levels by inhibiting its reuptake, while phenelzine, an MAOI, prevents the metabolic breakdown of serotonin. This synergistic effect leads to excessive serotonin accumulation in the central nervous system.
Clinical Management
Fluoxetine and phenelzine must not be used concurrently. A washout period is required when switching between these medications: at least 14 days after discontinuing phenelzine before starting fluoxetine, and at least 5 weeks after discontinuing fluoxetine before starting phenelzine.
The co-administration of escitalopram (an SSRI) and phenelzine (an MAOI) is absolutely contraindicated due to a significantly increased risk of Serotonin Syndrome, a potentially life-threatening condition characterized by mental status changes, autonomic instability, and neuromuscular abnormalities. This combination can lead to severe and fatal reactions.
Mechanism
Escitalopram inhibits the reuptake of serotonin, increasing its concentration in the synaptic cleft. Phenelzine inhibits monoamine oxidase enzymes, preventing the breakdown of serotonin. The combined effect leads to excessive serotonergic activity in the central nervous system.
Clinical Management
This combination is strictly contraindicated. Escitalopram must be discontinued for at least 14 days before initiating phenelzine. Conversely, phenelzine must be discontinued for at least 14 days before initiating escitalopram. Patients should be closely monitored for signs of Serotonin Syndrome if accidental co-administration occurs.
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