Medications for Major Depressive Disorder
ICD-10: F32
Medically Reviewed by Dr. Sarah Chen, PharmD, BCPS
Clinical Pharmacist & Medical Reviewer
Last reviewed: March 19, 2026
Overview
Major depressive disorder (MDD) affects over 21 million adults in the US. It is more than just feeling sad — it is a medical condition that affects how you feel, think, and handle daily activities.
Treatment Overview
Treatment typically combines psychotherapy (especially CBT) with antidepressant medications. SSRIs and SNRIs are the most commonly prescribed first-line medications.
15
Total Medications
0
First-Line Options
0
Off-Label Uses
Frequently Asked Questions
How long does it take for antidepressants to work?
Most antidepressants take 4–6 weeks to show full effect. Some improvement in sleep and energy may be noticed within 1–2 weeks, but mood improvements typically take longer.
Medical Disclaimer
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