Medications for Hyperlipidemia (High Cholesterol)
ICD-10: E78.5
Medically Reviewed by Dr. Sarah Chen, PharmD, BCPS
Clinical Pharmacist & Medical Reviewer
Last reviewed: March 19, 2026
Overview
High cholesterol is a major risk factor for cardiovascular disease, heart attack, and stroke. It has no symptoms and is detected through a blood test (lipid panel).
Treatment Overview
Treatment includes dietary changes (reducing saturated fats), exercise, and medications. Statins are the most effective and widely prescribed drug class for lowering LDL cholesterol.
7
Total Medications
7
First-Line Options
0
Off-Label Uses
First-Line Medications
Simvastatin
(Simvastatin)First-LineSimvastatin (Zocor) is a type of medicine called a statin, primarily used to lower high cholesterol and triglyceride levels in the blood. By reducing "bad" cholesterol and increasing "good" cholesterol, it helps decrease your risk of heart attack, stroke, and other heart-related problems. It works by blocking an enzyme in your liver that makes cholesterol.
Lovastatin
(Lovastatin)First-LineLOVASTATIN (brand name: Lovastatin) is a statin (HMG-CoA reductase inhibitor). Indications and Usage Therapy with lovastatin should be a component of multiple risk factor intervention in those individuals with dyslipidemia at risk for atherosclerotic vascular disease. Lovastatin should be used in addition to a diet restricted in saturated fat and cholesterol as part of a…
Atorvastatin
(Lipitor)First-LineAtorvastatin (Lipitor) is the world's best-selling prescription drug and the most widely prescribed statin for lowering LDL ('bad') cholesterol and reducing the risk of heart attack, stroke, and cardiovascular death. It is used for both primary prevention (in people without established heart disease but with risk factors) and secondary prevention (in people who have already had a heart attack or stroke). Generic atorvastatin is available for as little as $4–$25 per month.
Generic Available
Rosuvastatin
(Rosuvastatin Calcium)First-LineRosuvastatin is a medication in a class called "statins" that helps lower high cholesterol and other fats in your blood. It works by reducing the amount of "bad" cholesterol your body makes, which helps to prevent heart problems and slow the progression of hardening of the arteries.
Pravastatin
(Pravastatin Sodium)First-LinePravastatin is a statin medication used to lower high levels of "bad" cholesterol (LDL-C) in the blood. By reducing cholesterol production in the liver, it helps decrease the risk of serious heart problems like heart attacks and strokes. It is typically used along with a healthy diet.
Fluvastatin
(Fluvastatin)First-LineFluvastatin (brand names: Fluvastatin, Fluvastatin Sodium) is a type of medicine called a statin. It is primarily used to help lower high levels of "bad" cholesterol (like LDL-C) and fats (triglycerides) in the blood, and to increase "good" cholesterol (HDL-C), especially when diet and exercise alone aren't enough. It works by reducing the amount of cholesterol your body makes.
Pitavastatin
(Pitavastatin)First-LinePitavastatin is a "statin" medication used to lower high cholesterol levels in your blood. It works by reducing the amount of "bad" cholesterol (LDL-C) your body makes, helping to improve your overall cholesterol profile, especially in adults and children aged 8 and older with certain types of high cholesterol. This medicine is always used along with a healthy diet.
Frequently Asked Questions
What is a healthy LDL cholesterol level?
For most people, an LDL below 100 mg/dL is optimal. For people with heart disease or very high risk, the target is below 70 mg/dL. For very high-risk patients, below 55 mg/dL may be recommended.
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