Condition Guide

Medications for Hyperlipidemia (High Cholesterol)

ICD-10: E78.5

Medically Reviewed by Dr. Sarah Chen, PharmD, BCPS

Clinical Pharmacist & Medical Reviewer

Last reviewed: March 19, 2026

Overview

High cholesterol is a major risk factor for cardiovascular disease, heart attack, and stroke. It has no symptoms and is detected through a blood test (lipid panel).

Treatment Overview

Treatment includes dietary changes (reducing saturated fats), exercise, and medications. Statins are the most effective and widely prescribed drug class for lowering LDL cholesterol.

7

Total Medications

7

First-Line Options

0

Off-Label Uses

First-Line Medications

Simvastatin

(Simvastatin)First-Line

Simvastatin (Zocor) is a type of medicine called a statin, primarily used to lower high cholesterol and triglyceride levels in the blood. By reducing "bad" cholesterol and increasing "good" cholesterol, it helps decrease your risk of heart attack, stroke, and other heart-related problems. It works by blocking an enzyme in your liver that makes cholesterol.

$4–$20/month

Lovastatin

(Lovastatin)First-Line

LOVASTATIN (brand name: Lovastatin) is a statin (HMG-CoA reductase inhibitor). Indications and Usage Therapy with lovastatin should be a component of multiple risk factor intervention in those individuals with dyslipidemia at risk for atherosclerotic vascular disease. Lovastatin should be used in addition to a diet restricted in saturated fat and cholesterol as part of a…

$10-$30/month

Atorvastatin

(Lipitor)First-Line

Atorvastatin (Lipitor) is the world's best-selling prescription drug and the most widely prescribed statin for lowering LDL ('bad') cholesterol and reducing the risk of heart attack, stroke, and cardiovascular death. It is used for both primary prevention (in people without established heart disease but with risk factors) and secondary prevention (in people who have already had a heart attack or stroke). Generic atorvastatin is available for as little as $4–$25 per month.

$4–$25/month

Generic Available

Rosuvastatin

(Rosuvastatin Calcium)First-Line

Rosuvastatin is a medication in a class called "statins" that helps lower high cholesterol and other fats in your blood. It works by reducing the amount of "bad" cholesterol your body makes, which helps to prevent heart problems and slow the progression of hardening of the arteries.

$10–$40/month

Pravastatin

(Pravastatin Sodium)First-Line

Pravastatin is a statin medication used to lower high levels of "bad" cholesterol (LDL-C) in the blood. By reducing cholesterol production in the liver, it helps decrease the risk of serious heart problems like heart attacks and strokes. It is typically used along with a healthy diet.

$4–$25/month

Fluvastatin

(Fluvastatin)First-Line

Fluvastatin (brand names: Fluvastatin, Fluvastatin Sodium) is a type of medicine called a statin. It is primarily used to help lower high levels of "bad" cholesterol (like LDL-C) and fats (triglycerides) in the blood, and to increase "good" cholesterol (HDL-C), especially when diet and exercise alone aren't enough. It works by reducing the amount of cholesterol your body makes.

$10–$40/month

Pitavastatin

(Pitavastatin)First-Line

Pitavastatin is a "statin" medication used to lower high cholesterol levels in your blood. It works by reducing the amount of "bad" cholesterol (LDL-C) your body makes, helping to improve your overall cholesterol profile, especially in adults and children aged 8 and older with certain types of high cholesterol. This medicine is always used along with a healthy diet.

$200–$500/month

Frequently Asked Questions

What is a healthy LDL cholesterol level?

For most people, an LDL below 100 mg/dL is optimal. For people with heart disease or very high risk, the target is below 70 mg/dL. For very high-risk patients, below 55 mg/dL may be recommended.

Find the lowest price for any medication

Real-time prices at 67,000+ pharmacies · Free · No sign-up

Get the RxGo app — free prescription discounts on the go

Works at 67,000+ pharmacies · No membership needed

Download

Medical Disclaimer

The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.