Medications for Type 2 Diabetes
ICD-10: E11
Medically Reviewed by Dr. Sarah Chen, PharmD, BCPS
Clinical Pharmacist & Medical Reviewer
Last reviewed: March 19, 2026
Overview
Type 2 diabetes is the most common form of diabetes, accounting for 90–95% of all diabetes cases. It develops when the body becomes resistant to insulin or doesn't produce enough insulin to maintain normal blood glucose levels.
Treatment Overview
Treatment includes lifestyle modifications (diet, exercise, weight loss) and medications. Metformin is the first-line drug therapy. Additional medications are added as needed to achieve blood sugar targets.
23
Total Medications
0
First-Line Options
5
Off-Label Uses
Off-Label Uses
lovastatin
(Lovastatin)Off-LabelLOVASTATIN (brand name: Lovastatin) is a statin (HMG-CoA reductase inhibitor). Indications and Usage Therapy with lovastatin should be a component of multiple risk factor intervention in those individuals with dyslipidemia at risk for atherosclerotic vascular disease. Lovastatin should be used in addition to a diet restricted in saturated fat and cholesterol as part of a…
atorvastatin
(atorvastatin calcium)Off-LabelAtorvastatin (Lipitor) is a medication that belongs to a class of drugs called statins. It is primarily used to lower high cholesterol levels in the blood and reduce the risk of serious heart problems like heart attack and stroke. It works by helping your body produce less cholesterol.
CAPTOPRIL
(Captopril)Off-LabelCaptopril is a medication belonging to a class of drugs called ACE inhibitors, primarily used to treat high blood pressure (hypertension). It works by helping to relax blood vessels, which allows blood to flow more easily and lowers blood pressure.
LOSARTAN POTASSIUM
(Losartan Potassium)Off-LabelLosartan Potassium is a medication belonging to a class of drugs called angiotensin II receptor blockers (ARBs). It is primarily used to treat high blood pressure in adults and children, which helps reduce the risk of serious heart problems like strokes and heart attacks. It also helps protect the kidneys in people with type 2 diabetes and high blood pressure, and can lower the risk of stroke in patients with high blood pressure and an enlarged heart.
IRBESARTAN
(Irbesartan)Off-LabelIRBESARTAN (brand name: Irbesartan) is a ARBs. 1 INDICATIONS & USAGE Irbesartan tablet is an angiotensin II receptor blocker (ARB) indicated for: • Treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. ( 1.1 ) •…
Frequently Asked Questions
What is the difference between type 1 and type 2 diabetes?
Type 1 diabetes is an autoimmune condition where the body destroys insulin-producing cells. Type 2 is characterized by insulin resistance and relative insulin deficiency, strongly associated with lifestyle factors and genetics.
Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.