Tirzepatide Cost & Price Guide
Also sold as: Mounjaro, Mounjaro KwikPen, Zepbound
Tirzepatide is available under two brand names with different pricing structures: **Mounjaro (diabetes indication):** - List price: approximately $1,086–$1,112 per 4-week supply (all doses) - With commercial insurance savings card: as low as $25/month for eligible patients - Medicare Part D: covered for type 2 diabetes; prior authorization typically required **Zepbound (weight management indication):** - Autoinjector pen list price: approximately $1,086/month - Single-dose vials (2.5 mg, 5 mg) via LillyDirect: $299–$549/month — the most affordable option for patients paying out of pocket - With commercial insurance savings card: as low as $25/month - Medicare Part D: does not cover Zepbound for weight loss; covers for OSA indication starting April 2026 at ~$50/month copay No FDA-approved generic tirzepatide exists as of 2026. Compounded tirzepatide is no longer permitted under the shortage exemption following the FDA's declaration that the shortage has been resolved.
Per month, without insurance
Only brand-name versions currently available
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Cost Overview
Tirzepatide is available under two brand names with different pricing structures:
Mounjaro (diabetes indication):
- List price: approximately $1,086–$1,112 per 4-week supply (all doses)
- With commercial insurance savings card: as low as $25/month for eligible patients
- Medicare Part D: covered for type 2 diabetes; prior authorization typically required
Zepbound (weight management indication):
- Autoinjector pen list price: approximately $1,086/month
- Single-dose vials (2.5 mg, 5 mg) via LillyDirect: $299–$549/month — the most affordable option for patients paying out of pocket
- With commercial insurance savings card: as low as $25/month
- Medicare Part D: does not cover Zepbound for weight loss; covers for OSA indication starting April 2026 at ~$50/month copay
No FDA-approved generic tirzepatide exists as of 2026. Compounded tirzepatide is no longer permitted under the shortage exemption following the FDA's declaration that the shortage has been resolved.
Generic vs. Brand-Name Price
| Version | Typical Monthly Cost | Notes |
|---|---|---|
| Mounjaro(brand) | $299–$1,112/month | Check manufacturer patient assistance programs |
| Mounjaro KwikPen(brand) | $299–$1,112/month | Check manufacturer patient assistance programs |
| Zepbound(brand) | $299–$1,112/month | Check manufacturer patient assistance programs |
Available Forms & Strengths
Tirzepatide is available in the following dosage forms. Prices may vary by form and strength.
Ways to Save on Tirzepatide
Prescription Discount Cards
Free discount programs like GoodRx, RxSaver, and NeedyMeds can reduce the cost of tirzepatide at most pharmacies. Compare prices before filling.
90-Day Supply
Ordering a 90-day supply through a mail-order pharmacy often costs less per dose than monthly fills. Check with your insurance plan or pharmacy benefit manager.
Patient Assistance Programs
If you're uninsured or underinsured, the manufacturer may offer a patient assistance program (PAP) that provides tirzepatide at low or no cost. Visit NeedyMeds.org or the manufacturer's website.
Insurance Coverage
Most insurance plans, including Medicare Part D and Medicaid, cover tirzepatide . Coverage and copay amounts vary by plan tier and formulary. Contact your insurance provider or check your plan's drug formulary to confirm coverage.
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Patient Assistance Programs (PAP)
If you're uninsured, underinsured, or cannot afford tirzepatide, these programs may provide it at low or no cost.
Frequently Asked Questions About Tirzepatide Cost
What is tirzepatide used for?
Tirzepatide is used for two main conditions: (1) type 2 diabetes — sold as Mounjaro, approved May 2022; and (2) chronic weight management and obstructive sleep apnea — sold as Zepbound, approved November 2023. Both brands contain the same active ingredient at the same doses.
How is tirzepatide different from semaglutide (Ozempic, Wegovy)?
Semaglutide activates only the GLP-1 receptor. Tirzepatide activates both the GLP-1 and GIP receptors simultaneously — a dual mechanism that produces stronger blood sugar control and greater weight loss. In the SURMOUNT-5 trial, tirzepatide produced 20.2% weight loss versus 13.7% with semaglutide 2.4 mg at 72 weeks.
How do you inject tirzepatide?
Tirzepatide is injected subcutaneously (under the skin) once weekly in the abdomen, thigh, or upper arm. It can be given at any time of day, with or without food. Rotate injection sites with each dose to reduce injection site reactions.
What are the most common side effects of tirzepatide?
The most common side effects are gastrointestinal: nausea (12–22%), diarrhea (12–16%), vomiting (6–13%), constipation (6–9%), and abdominal pain (8–11%). These are most pronounced during dose escalation and typically improve after the first 4–8 weeks. Starting at the lowest dose (2.5 mg) and titrating slowly reduces GI side effects.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.