Amlodipine Besylate Drug Interactions
Also known as: Norvasc, Katerzia, Norliqva
Amlodipine (Norvasc) is a long-acting dihydropyridine calcium channel blocker (CCB) used to treat high blood pressure (hypertension), chronic stable angina, vasospastic (Prinzmetal's) angina, and coronary artery disease. It is one of the most widely prescribed medications in the United States, known for its once-daily dosing, excellent tolerability, and proven cardiovascular outcomes data from the ALLHAT and CAMELOT trials. Amlodipine is available as a generic for as little as $4/month.Amlodipine Besylate has 1 documented drug interaction in our database, including 0 contraindicated, 0 major, 1 moderate, and 0 minor interactions.
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Contraindicated
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Major
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Moderate
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Minor
The combination of valsartan and amlodipine can lead to an additive hypotensive effect, potentially causing symptomatic hypotension, especially in patients who are volume-depleted or on other antihypertensive medications. While often used together for synergistic blood pressure reduction, close monitoring is warranted.
Mechanism
Valsartan, an angiotensin receptor blocker (ARB), and amlodipine, a dihydropyridine calcium channel blocker (CCB), both lower blood pressure through different mechanisms. Their concurrent use results in an additive pharmacodynamic effect on blood pressure.
Clinical Management
Monitor blood pressure regularly, especially during initiation or dose titration of either medication. Adjust doses as needed to achieve target blood pressure while avoiding symptomatic hypotension. Educate patients about symptoms of low blood pressure, such as dizziness or lightheadedness.
For complete prescribing information:
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