LIRAGLUTIDE Drug Interactions
Also known as: Victoza
Liraglutide (Victoza) is a type of medicine that mimics a natural hormone in your body. It is prescribed to help adults and children aged 10 and older with type 2 diabetes manage their blood sugar levels, and it can also lower the risk of serious heart problems like heart attack or stroke in adults with type 2 diabetes and existing heart disease. It works by helping your body release insulin when needed and reducing the amount of sugar your liver makes.LIRAGLUTIDE has 1 documented drug interaction in our database, including 0 contraindicated, 0 major, 1 moderate, and 0 minor interactions.
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Contraindicated
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Major
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Moderate
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Minor
Combining semaglutide and liraglutide, both GLP-1 receptor agonists, is generally not recommended. This combination is unlikely to provide additional glycemic control or weight loss benefits beyond monotherapy, but significantly increases the risk of dose-dependent adverse effects.
Mechanism
Both semaglutide and liraglutide act as glucagon-like peptide-1 (GLP-1) receptor agonists, stimulating insulin secretion, suppressing glucagon release, slowing gastric emptying, and promoting satiety. Concomitant use leads to additive pharmacological effects on the GLP-1 receptor.
Clinical Management
Concomitant use of semaglutide and liraglutide should be avoided. If a patient is not achieving desired outcomes on one GLP-1 agonist, consider optimizing the dose, switching to a different class of antidiabetic medication, or adding another agent from a different class, rather than combining two GLP-1 agonists. Monitor for increased gastrointestinal side effects if inadvertently co-administered.
For complete prescribing information:
View full LIRAGLUTIDE monograph →Medical Disclaimer
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