LISINOPRIL Drug Interactions
Also known as: Lisinopril
Lisinopril is a medication in a class called ACE inhibitors. It is primarily used to treat high blood pressure, help manage heart failure, and improve outcomes after a heart attack. This medication works by relaxing blood vessels, which helps to lower blood pressure and reduce the strain on your heart.LISINOPRIL has 3 documented drug interactions in our database, including 0 contraindicated, 1 major, 2 moderate, and 0 minor interactions.
0
Contraindicated
1
Major
2
Moderate
0
Minor
Dual blockade of the renin-angiotensin system with an ACE inhibitor and ARB increases the risk of hypotension, hyperkalemia, and acute kidney injury.
Mechanism
Both drug classes independently block the RAAS pathway. Combined use provides no additional cardiovascular benefit but doubles the risk of adverse renal and electrolyte effects.
Clinical Management
Avoid combination in most patients. If used, monitor blood pressure, renal function, and potassium closely.
NSAIDs can reduce the antihypertensive effect of ACE inhibitors and increase the risk of acute kidney injury.
Mechanism
NSAIDs inhibit prostaglandin synthesis, reducing renal afferent arteriole dilation and blunting the renal protective effects of ACE inhibitors.
Clinical Management
Monitor blood pressure and renal function. Use acetaminophen as an alternative when possible.
Concomitant use of lisinopril and ibuprofen can increase the risk of acute kidney injury, particularly in elderly or volume-depleted patients. It may also reduce the antihypertensive effects of lisinopril, leading to uncontrolled blood pressure.
Mechanism
Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), inhibits prostaglandin synthesis. Prostaglandins are crucial for maintaining renal blood flow, especially when the renin-angiotensin-aldosterone system (RAAS) is inhibited by lisinopril. This can lead to impaired renal function and fluid retention.
Clinical Management
Avoid concomitant use if possible, especially in patients at high risk for renal impairment (e.g., elderly, dehydrated, heart failure). If co-administration is necessary, monitor renal function (serum creatinine, BUN) and blood pressure closely, particularly at initiation and dose changes. Advise patients to maintain adequate hydration.
For complete prescribing information:
View full LISINOPRIL monograph →Medical Disclaimer
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