LOSARTAN POTASSIUM Drug Interactions
Also known as: Losartan Potassium
Losartan Potassium is a medication belonging to a class of drugs called angiotensin II receptor blockers (ARBs). It is primarily used to treat high blood pressure in adults and children, which helps reduce the risk of serious heart problems like strokes and heart attacks. It also helps protect the kidneys in people with type 2 diabetes and high blood pressure, and can lower the risk of stroke in patients with high blood pressure and an enlarged heart.LOSARTAN POTASSIUM has 2 documented drug interactions in our database, including 0 contraindicated, 1 major, 1 moderate, and 0 minor interactions.
0
Contraindicated
1
Major
1
Moderate
0
Minor
Dual blockade of the renin-angiotensin system with an ACE inhibitor and ARB increases the risk of hypotension, hyperkalemia, and acute kidney injury.
Mechanism
Both drug classes independently block the RAAS pathway. Combined use provides no additional cardiovascular benefit but doubles the risk of adverse renal and electrolyte effects.
Clinical Management
Avoid combination in most patients. If used, monitor blood pressure, renal function, and potassium closely.
Concomitant use of ibuprofen and losartan can lead to a decrease in the antihypertensive effect of losartan and an increased risk of renal dysfunction, particularly in elderly, dehydrated, or renally impaired patients. This combination can also increase the risk of hyperkalemia.
Mechanism
Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), inhibits prostaglandin synthesis, which can counteract the vasodilator effects of losartan and lead to sodium and water retention. In susceptible patients, this can impair renal perfusion and function when combined with the angiotensin receptor blockade of losartan.
Clinical Management
Monitor blood pressure closely when initiating or discontinuing ibuprofen in patients on losartan. Assess renal function (e.g., serum creatinine, GFR) and serum potassium levels regularly, especially in high-risk patients. Advise patients to maintain adequate hydration.
For complete prescribing information:
View full LOSARTAN POTASSIUM monograph →Medical Disclaimer
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