rosuvastatin Drug Interactions
Also known as: ROSUVASTATIN CALCIUM, Rosuvastatin, Crestor
Rosuvastatin is a medication in a class called "statins" that helps lower high cholesterol and other fats in your blood. It works by reducing the amount of "bad" cholesterol your body makes, which helps to prevent heart problems and slow the progression of hardening of the arteries.rosuvastatin has 1 documented drug interaction in our database, including 0 contraindicated, 0 major, 1 moderate, and 0 minor interactions.
0
Contraindicated
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Major
1
Moderate
0
Minor
Concomitant use of atorvastatin and rosuvastatin is generally not recommended as it significantly increases the risk of dose-dependent statin-related adverse effects, particularly myopathy and rhabdomyolysis, without providing substantial additional lipid-lowering benefit. While both drugs lower cholesterol, combining them primarily elevates safety concerns.
Mechanism
Both atorvastatin and rosuvastatin are HMG-CoA reductase inhibitors, and their co-administration leads to an additive pharmacological effect, increasing systemic exposure to statins. This heightened exposure saturates metabolic pathways and increases the likelihood of dose-related toxicities, especially muscle-related adverse events.
Clinical Management
The co-administration of atorvastatin and rosuvastatin should generally be avoided. If a patient requires more intensive lipid lowering than a single statin can provide, alternative strategies such as increasing the dose of a single statin (within recommended limits), or adding a non-statin lipid-lowering agent (e.g., ezetimibe, PCSK9 inhibitor) should be considered. Monitor patients closely for muscle pain, tenderness, or weakness if this combination is inadvertently used.
For complete prescribing information:
View full rosuvastatin monograph →Medical Disclaimer
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