SEMAGLUTIDE Drug Interactions
Also known as: WEGOVY
Wegovy is a prescription medication that belongs to a class of drugs called GLP-1 receptor agonists. It is used alongside a reduced-calorie diet and increased physical activity to help adults and children aged 12 and older lose weight and keep it off, especially for those with obesity or who are overweight with related health conditions. Wegovy also helps reduce the risk of serious heart problems like heart attack or stroke in adults with existing heart disease and obesity or overweight.SEMAGLUTIDE has 1 documented drug interaction in our database, including 0 contraindicated, 0 major, 1 moderate, and 0 minor interactions.
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Contraindicated
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Major
1
Moderate
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Minor
Combining semaglutide and liraglutide, both GLP-1 receptor agonists, is generally not recommended. This combination is unlikely to provide additional glycemic control or weight loss benefits beyond monotherapy, but significantly increases the risk of dose-dependent adverse effects.
Mechanism
Both semaglutide and liraglutide act as glucagon-like peptide-1 (GLP-1) receptor agonists, stimulating insulin secretion, suppressing glucagon release, slowing gastric emptying, and promoting satiety. Concomitant use leads to additive pharmacological effects on the GLP-1 receptor.
Clinical Management
Concomitant use of semaglutide and liraglutide should be avoided. If a patient is not achieving desired outcomes on one GLP-1 agonist, consider optimizing the dose, switching to a different class of antidiabetic medication, or adding another agent from a different class, rather than combining two GLP-1 agonists. Monitor for increased gastrointestinal side effects if inadvertently co-administered.
For complete prescribing information:
View full SEMAGLUTIDE monograph →Medical Disclaimer
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