Lisinopril Cost & Price Guide
Also sold as: Prinivil, Zestril, Zestoretic (with hydrochlorothiazide), Prinzide (with hydrochlorothiazide)
Generic lisinopril is one of the most affordable prescription medications in the US: - **5 mg, 10 mg, 20 mg, 40 mg tablets:** $4–$15/month at most major pharmacies (Walmart, Kroger, Publix $4 generic programs) - **Brand-name Prinivil or Zestril:** Rarely prescribed due to identical efficacy of generics; $100–$300+/month **GoodRx and discount cards** can reduce costs to under $5/month at many pharmacies. Lisinopril is covered by virtually all insurance plans as a Tier 1 (lowest cost) drug on most formularies. **Combination products:** - Zestoretic (lisinopril + hydrochlorothiazide): $10–$30/month (generic) - Prinzide (lisinopril + hydrochlorothiazide): generic available ~$10–$25/month
Per month, without insurance
Generic versions may cost significantly less
Discount coupons may reduce out-of-pocket costs
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Cost Overview
Generic lisinopril is one of the most affordable prescription medications in the US:
- 5 mg, 10 mg, 20 mg, 40 mg tablets: $4–$15/month at most major pharmacies (Walmart, Kroger, Publix $4 generic programs)
- Brand-name Prinivil or Zestril: Rarely prescribed due to identical efficacy of generics; $100–$300+/month
GoodRx and discount cards can reduce costs to under $5/month at many pharmacies. Lisinopril is covered by virtually all insurance plans as a Tier 1 (lowest cost) drug on most formularies.
Combination products:
- Zestoretic (lisinopril + hydrochlorothiazide): $10–$30/month (generic)
- Prinzide (lisinopril + hydrochlorothiazide): generic available ~$10–$25/month
Generic vs. Brand-Name Price
| Version | Typical Monthly Cost | Notes |
|---|---|---|
lisinopril (generic)Best Value | $4–$15/month | Same active ingredient as brand; FDA-approved bioequivalent |
| Prinivil(brand) | Typically higher than generic | Manufacturer coupons may reduce cost |
| Zestril(brand) | Typically higher than generic | Manufacturer coupons may reduce cost |
| Zestoretic (with hydrochlorothiazide)(brand) | Typically higher than generic | Manufacturer coupons may reduce cost |
Generic Manufacturers
The following companies manufacture FDA-approved generic versions of Lisinopril. Prices may vary between manufacturers and pharmacies.
Available Forms & Strengths
Lisinopril is available in the following dosage forms. Prices may vary by form and strength.
Ways to Save on Lisinopril
Ask for the Generic
Generic lisinopril contains the same active ingredient and is FDA-approved as bioequivalent to the brand. Ask your pharmacist to dispense the generic to save significantly.
Prescription Discount Cards
Free discount programs like GoodRx, RxSaver, and NeedyMeds can reduce the cost of lisinopril at most pharmacies. Compare prices before filling.
90-Day Supply
Ordering a 90-day supply through a mail-order pharmacy often costs less per dose than monthly fills. Check with your insurance plan or pharmacy benefit manager.
Patient Assistance Programs
If you're uninsured or underinsured, the manufacturer may offer a patient assistance program (PAP) that provides lisinopril at low or no cost. Visit NeedyMeds.org or the manufacturer's website.
Insurance Coverage
Most insurance plans, including Medicare Part D and Medicaid, cover lisinopril (particularly the generic version). Coverage and copay amounts vary by plan tier and formulary. Contact your insurance provider or check your plan's drug formulary to confirm coverage.
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Patient Assistance Programs (PAP)
If you're uninsured, underinsured, or cannot afford lisinopril, these programs may provide it at low or no cost.
Frequently Asked Questions About Lisinopril Cost
What is the best time of day to take lisinopril?
Lisinopril can be taken at any time of day, but many doctors recommend taking it in the morning to align with the natural circadian rise in blood pressure. If you experience dizziness or lightheadedness (especially with your first dose), taking it at bedtime can minimize this effect. The most important thing is to take it at the same time every day. Lisinopril's 12-hour half-life provides 24-hour blood pressure control with once-daily dosing.
Why does lisinopril cause a dry cough?
The dry, persistent cough is caused by the accumulation of bradykinin in the airways. ACE (angiotensin-converting enzyme) normally breaks down bradykinin — when lisinopril blocks ACE, bradykinin builds up and irritates the airways, triggering a cough reflex. This affects 10–20% of patients (up to 40% in Asian populations) and is the most common reason for stopping lisinopril. The cough typically resolves within 1–4 weeks of discontinuation. If the cough is intolerable, your doctor can switch you to an ARB (such as losartan or valsartan), which provides similar blood pressure and kidney protection without causing cough.
Can I take ibuprofen or naproxen with lisinopril?
Regular use of NSAIDs (ibuprofen, naproxen, aspirin >325 mg/day, celecoxib) with lisinopril is not recommended. NSAIDs reduce the blood pressure-lowering effect of lisinopril, can cause acute kidney injury (especially in elderly or volume-depleted patients), and increase potassium levels. For pain relief, acetaminophen (Tylenol) is the preferred alternative. Occasional low-dose ibuprofen use is generally acceptable in otherwise healthy patients, but discuss with your doctor if you need regular pain medication.
What are the signs of angioedema from lisinopril?
Angioedema is a rare but potentially life-threatening reaction to lisinopril. Warning signs include sudden swelling of the face, lips, tongue, throat, or hands — often without hives or itching. Throat swelling (laryngeal angioedema) can block the airway and is a medical emergency. If you experience any swelling of the face, lips, tongue, or throat, stop lisinopril immediately and go to the emergency room or call 911. Do not take another ACE inhibitor after angioedema — you can be switched to an ARB instead.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.