OXYCODONE HYDROCHLORIDE Drug Interactions
Also known as: Oxycodone Hydrochloride
OXYCODONE HYDROCHLORIDE (brand name: Oxycodone Hydrochloride) is a Opioid Analgesics. 1 INDICATIONS AND USAGE Oxycodone Hydrochloride Tablets, USP are indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Oxycodone hydrochloride tablets are an opioid agonist indicated for the management of pain severe…OXYCODONE HYDROCHLORIDE has 4 documented drug interactions in our database, including 0 contraindicated, 3 major, 1 moderate, and 0 minor interactions.
0
Contraindicated
3
Major
1
Moderate
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Minor
Concomitant use of oxycodone and lorazepam can lead to profound sedation, respiratory depression, coma, and death. This interaction significantly increases the risk of life-threatening adverse effects due to central nervous system (CNS) depression.
Mechanism
Both oxycodone (an opioid) and lorazepam (a benzodiazepine) are CNS depressants. Their co-administration results in an additive depressant effect on the CNS, particularly on respiratory drive and consciousness.
Clinical Management
Avoid concomitant use whenever possible. If co-prescription is unavoidable, use the lowest effective doses for the shortest duration, monitor patients closely for signs of respiratory depression and sedation, and counsel patients and caregivers on these risks.
Concomitant use of oxycodone, an opioid, and diazepam, a benzodiazepine, can lead to profound sedation, respiratory depression, coma, and death. Patients should be closely monitored for these severe adverse effects.
Mechanism
Both oxycodone and diazepam are central nervous system (CNS) depressants. Oxycodone acts as a mu-opioid receptor agonist, while diazepam enhances the effect of the inhibitory neurotransmitter GABA. Their combined CNS depressant effects are additive, leading to increased risk of respiratory depression and sedation.
Clinical Management
Avoid concomitant use if possible. If co-administration is unavoidable, prescribe the lowest effective doses and shortest durations. Closely monitor patients for respiratory depression and sedation, and educate them on the risks.
Co-administration of oxycodone and alprazolam can lead to profound sedation, respiratory depression, coma, and death. This interaction significantly increases the risk of life-threatening adverse effects due to additive central nervous system (CNS) depressant effects.
Mechanism
Oxycodone is an opioid agonist that causes CNS depression, while alprazolam is a benzodiazepine that enhances the effect of GABA, leading to further CNS depression. The combined pharmacodynamic effects result in additive respiratory and CNS depressant activity.
Clinical Management
Avoid concomitant use of oxycodone and alprazolam. If co-prescription is unavoidable, use the lowest effective doses for the shortest possible duration, and monitor patients closely for signs of respiratory depression and sedation. Consider alternative treatments that do not interact.
Concomitant use of oxycodone and fluoxetine can increase oxycodone plasma concentrations, potentially leading to enhanced opioid effects such as respiratory depression, sedation, and constipation. Conversely, fluoxetine may reduce the analgesic efficacy of oxycodone.
Mechanism
Fluoxetine is a potent inhibitor of CYP2D6, the enzyme responsible for converting oxycodone to its active metabolite oxymorphone. This inhibition leads to increased oxycodone levels and decreased oxymorphone levels, altering the overall opioid effect.
Clinical Management
Monitor patients closely for signs of increased opioid effects (e.g., sedation, respiratory depression) or reduced analgesia when these drugs are co-administered. Consider starting with lower oxycodone doses or adjusting existing doses, and be prepared to manage adverse events. An alternative opioid or antidepressant may be considered.
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