Combining Diazepam and Oxycodone Hydrochloride is a major interaction and should generally be avoided without close medical supervision.
Concomitant use of oxycodone, an opioid, and diazepam, a benzodiazepine, can lead to profound sedation, respiratory depression, coma, and death. Patients should be closely monitored for these severe adverse effects.
Mechanism: Both oxycodone and diazepam are central nervous system (CNS) depressants. Oxycodone acts as a mu-opioid receptor agonist, while diazepam enhances the effect of the inhibitory neurotransmitter GABA. Their combined CNS depressant effects are additive, leading to increased risk of respiratory depression and sedation.
Diazepam vs. Oxycodone Hydrochloride
Compare Diazepam and Oxycodone Hydrochloride: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Diazepam
Diazepam
Benzodiazepines
RxDrug B
Oxycodone Hydrochloride
Oxycodone Hydrochloride
Opioid Analgesics
RxQuick Comparison
| Category | Diazepam | Oxycodone Hydrochloride |
|---|---|---|
| Drug Class | Benzodiazepines | Opioid Analgesics |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $10–$50/month | $50–$300/month |
Diazepam Overview
Diazepam is a medication in the benzodiazepine class that works by calming the brain and nerves. It is primarily used to treat anxiety disorders, relieve symptoms of acute alcohol withdrawal, and help relax muscles to ease spasms.
Full Diazepam guide →Oxycodone Hydrochloride Overview
OXYCODONE HYDROCHLORIDE (brand name: Oxycodone Hydrochloride) is a Opioid Analgesics. 1 INDICATIONS AND USAGE Oxycodone Hydrochloride Tablets, USP are indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Oxycodone hydrochloride tablets are an opioid agonist indicated for the management of pain severe…
Full Oxycodone Hydrochloride guide →How Each Drug Works
Oxycodone Hydrochloride
Oxycodone is a full opioid agonist and is relatively selective for the mu-opioid receptor, although it can bind to other opioid receptors at higher doses. The principal therapeutic action of oxycodone is analgesia. Like all full opioid agonists, there is no ceiling effect for analgesia with oxycodone. Clinically, dosage is titrated to provide adequate analgesia and may be limited by adverse reactions, including respiratory and CNS depression. The precise mechanism of the…
Approved Uses (Indications)
Diazepam
INDICATIONS AND USAGE Diazepam tablets are indicated for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic. In acute alcohol withdrawal, diazepam tablets may be useful in the symptomatic relief of acute agitation, tremor, impending or acute delirium tremens and hallucinosis. Diazepam tablets are a useful adjunct for the relief of skeletal muscle spasm due to reflex spasm to local pathology (such as inflammation of the muscles or joints,…
Oxycodone Hydrochloride
Oxycodone Hydrochloride Tablets, USP are indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Oxycodone hydrochloride tablets are an opioid agonist indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Limitations of Use: Because of the risks of addiction, abuse, and misuse with opioids, which can occur at any dosage or duration, reserve oxycodone hydrochloride tablets for use in patients for whom altern…
Side Effects
Diazepam
Oxycodone Hydrochloride
Cost Comparison
Diazepam
$10–$50/month
Diazepam is available as a low-cost generic. Patients can often find significant savings by using discount cards or pharmacy coupon programs.
Oxycodone Hydrochloride
$50–$300/month
While a generic is not available, discount cards like GoodRx can often help reduce the cost. Patients should also inquire about patient assistance programs offered by manufacturers or non-profit organizations.
Compare prices for Diazepam and Oxycodone Hydrochloride
Check real-time pharmacy prices before you fill — free, no account needed.
Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.