Combining Lorazepam and Oxycodone Hydrochloride is a major interaction and should generally be avoided without close medical supervision.
Concomitant use of oxycodone and lorazepam can lead to profound sedation, respiratory depression, coma, and death. This interaction significantly increases the risk of life-threatening adverse effects due to central nervous system (CNS) depression.
Mechanism: Both oxycodone (an opioid) and lorazepam (a benzodiazepine) are CNS depressants. Their co-administration results in an additive depressant effect on the CNS, particularly on respiratory drive and consciousness.
Lorazepam vs. Oxycodone Hydrochloride
Compare Lorazepam and Oxycodone Hydrochloride: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Lorazepam
Lorazepam
Benzodiazepines
RxDrug B
Oxycodone Hydrochloride
Oxycodone Hydrochloride
Opioid Analgesics
RxQuick Comparison
| Category | Lorazepam | Oxycodone Hydrochloride |
|---|---|---|
| Drug Class | Benzodiazepines | Opioid Analgesics |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $10–$50/month | $50–$300/month |
Lorazepam Overview
Lorazepam is a prescription medication used to help manage anxiety disorders and provide short-term relief from anxiety symptoms. It works by calming the brain and nerves, which can help reduce feelings of worry and tension.
Full Lorazepam guide →Oxycodone Hydrochloride Overview
OXYCODONE HYDROCHLORIDE (brand name: Oxycodone Hydrochloride) is a Opioid Analgesics. 1 INDICATIONS AND USAGE Oxycodone Hydrochloride Tablets, USP are indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Oxycodone hydrochloride tablets are an opioid agonist indicated for the management of pain severe…
Full Oxycodone Hydrochloride guide →How Each Drug Works
Oxycodone Hydrochloride
Oxycodone is a full opioid agonist and is relatively selective for the mu-opioid receptor, although it can bind to other opioid receptors at higher doses. The principal therapeutic action of oxycodone is analgesia. Like all full opioid agonists, there is no ceiling effect for analgesia with oxycodone. Clinically, dosage is titrated to provide adequate analgesia and may be limited by adverse reactions, including respiratory and CNS depression. The precise mechanism of the…
Approved Uses (Indications)
Lorazepam
INDICATIONS AND USAGE Lorazepam tablets are indicated for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic. The effectiveness of lorazepam tablets in long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. The physician should periodically reassess the usefulness of the drug for the individual patient.
Oxycodone Hydrochloride
Oxycodone Hydrochloride Tablets, USP are indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Oxycodone hydrochloride tablets are an opioid agonist indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Limitations of Use: Because of the risks of addiction, abuse, and misuse with opioids, which can occur at any dosage or duration, reserve oxycodone hydrochloride tablets for use in patients for whom altern…
Side Effects
Lorazepam
Oxycodone Hydrochloride
Cost Comparison
Lorazepam
$10–$50/month
Lorazepam is a widely available generic, making it relatively inexpensive. Patients can often find significant savings by using discount cards or comparing prices at different pharmacies.
Oxycodone Hydrochloride
$50–$300/month
While a generic is not available, discount cards like GoodRx can often help reduce the cost. Patients should also inquire about patient assistance programs offered by manufacturers or non-profit organizations.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.