Levothyroxine Cost Without Insurance 2026: $4

Levothyroxine Cost Without Insurance (2026 Guide)

Levothyroxine is one of the most affordable prescription drugs in the US — generic versions cost as little as $4/month. But prices vary significantly by pharmacy, dose, and brand. Here is how to pay as little as possible.

By James Okafor, RPh, MBA

Medically reviewed by Dr. Sarah Chen, PharmD, BCPS

Published June 21, 2026

Last reviewed June 15, 2026

2 min read

How Much Does Levothyroxine Cost?

Levothyroxine is one of the most affordable prescription medications available. Generic levothyroxine typically costs $4–$15 per month for a 30-day supply, making it accessible even without insurance. Brand-name Synthroid costs significantly more — $30–$60/month — but is rarely necessary for most patients.

Levothyroxine Price by Dose (2026)

Dose	Generic (30-day)	Synthroid (30-day)	With GoodRx/RxGo
25 mcg	$4–$10	$30–$45	$4–$8
50 mcg	$4–$12	$30–$50	$4–$9
75 mcg	$4–$12	$35–$55	$4–$10
88 mcg	$4–$12	$35–$55	$4–$10
100 mcg	$4–$15	$40–$60	$5–$12
112 mcg	$4–$15	$40–$60	$5–$12
125 mcg	$5–$15	$40–$60	$5–$12
150 mcg	$5–$15	$45–$65	$5–$13
175 mcg	$5–$18	$45–$65	$5–$14
200 mcg	$5–$18	$50–$70	$5–$15

Cheapest Pharmacies for Levothyroxine

Pharmacy	Generic Price (100 mcg, 30-day)	Notes
Walmart	$4–$9	$4 generic program; most doses available
Costco	$4–$8	Membership not required for pharmacy
Mark Cuban Cost Plus Drugs	~$3–$6	Transparent pricing; requires prescription
Kroger/Fry's	$4–$10	Generic drug program
CVS	$10–$20	Lower with GoodRx or RxGo card
Walgreens	$10–$25	Lower with discount card
Rite Aid	$10–$20	Lower with discount card

Brand vs. Generic: Is Synthroid Worth the Extra Cost?

Synthroid (Abbott) is the original brand-name levothyroxine and costs 3–5× more than generic versions. For most patients, generic levothyroxine is equally effective. However, levothyroxine has a narrow therapeutic index, meaning small differences in bioavailability can affect TSH levels.

The key principle is consistency: it does not matter whether you take brand-name or generic levothyroxine, but you should stay on the same product consistently. If your pharmacy switches your generic manufacturer, ask your doctor if a TSH recheck is warranted.

Tirosint (liquid gel capsule) is a premium formulation that avoids absorption issues caused by fillers and is useful for patients with GI conditions or those taking proton pump inhibitors. It costs $60–$120/month but may be covered by insurance.

Insurance Coverage for Levothyroxine

Generic levothyroxine is on virtually every insurance formulary, typically at Tier 1 (lowest copay — often $0–$10/month). Brand-name Synthroid may be on Tier 2 or 3, with copays of $20–$50/month. Medicare Part D covers generic levothyroxine at very low cost.

How to Save on Levothyroxine

Use a discount card — GoodRx or RxGo can reduce generic levothyroxine to $4–$10 at most pharmacies
Shop at Walmart or Costco — their generic drug programs offer the lowest cash prices
Ask for a 90-day supply — most pharmacies offer a discount for 90-day fills vs. 30-day fills
Try Mark Cuban's Cost Plus Drugs — transparent pricing often beats GoodRx for levothyroxine
Synthroid savings card — AbbVie offers a savings card for Synthroid that can reduce cost to $25–$35/month for eligible patients

Does Medicare Cover Levothyroxine?

Yes. Generic levothyroxine is covered by Medicare Part D at Tier 1 on most plans, with typical copays of $0–$5/month. Brand-name Synthroid may have higher copays under Part D. The Medicare Extra Help program (Low Income Subsidy) can further reduce costs for eligible beneficiaries.

For more information about levothyroxine, see our complete levothyroxine guide, levothyroxine vs. liothyronine comparison, and levothyroxine drug monograph.