Condition Guide

Medications for Obesity

ICD-10: E66

Medically Reviewed by Dr. Sarah Chen, PharmD, BCPS

Clinical Pharmacist & Medical Reviewer

Last reviewed: March 19, 2026

Overview

Obesity affects 42% of American adults and is a major risk factor for type 2 diabetes, cardiovascular disease, sleep apnea, and certain cancers. It is now recognized as a chronic disease requiring long-term management.

Treatment Overview

Treatment includes intensive lifestyle intervention, behavioral therapy, pharmacotherapy, and bariatric surgery for severe cases. GLP-1 receptor agonists represent a major advance in pharmacological treatment.

Total Medications

First-Line Options

Off-Label Uses

metformin

(Glucophage)Off-Label

Metformin (brand name: Glucophage) is the first-line oral medication for type 2 diabetes. It works by reducing glucose production in the liver and improving insulin sensitivity in muscle and fat tissue.

$4–$15/month

Generic Available

Frequently Asked Questions

What BMI is considered obese?

A BMI of 30 or higher is classified as obese. Class I obesity: BMI 30–34.9. Class II: BMI 35–39.9. Class III (severe): BMI ≥ 40.

Medical Disclaimer

The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.