Combining Amiodarone Hydrochloride and Digoxin is a major interaction and should generally be avoided without close medical supervision.
Amiodarone significantly increases digoxin serum concentrations, potentially leading to digoxin toxicity. Patients may experience symptoms such as nausea, vomiting, visual disturbances, and life-threatening arrhythmias. This interaction can occur even with previously stable digoxin doses.
Mechanism: Amiodarone inhibits P-glycoprotein (P-gp), a transporter responsible for digoxin efflux from enterocytes and renal tubular cells. This inhibition reduces digoxin's intestinal secretion and renal clearance, leading to increased systemic exposure and prolonged half-life.
Amiodarone Hydrochloride vs. Digoxin
Compare Amiodarone Hydrochloride and Digoxin: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Amiodarone Hydrochloride
Amiodarone Hydrochloride
Antiarrhythmics
RxDrug B
Digoxin
Digoxin
Cardiac Glycosides
RxQuick Comparison
| Category | Amiodarone Hydrochloride | Digoxin |
|---|---|---|
| Drug Class | Antiarrhythmics | Cardiac Glycosides |
| Rx Status | Rx | Rx |
| Generic Available | Yes | Yes |
| Typical Cost | $30-$80/month | $10-$50/month |
Amiodarone Hydrochloride Overview
AMIODARONE HYDROCHLORIDE (brand name: Amiodarone Hydrochloride) is a Antiarrhythmics. 1 INDICATIONS AND USAGE Amiodarone Hydrochloride Injection, USP is indicated for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation (VF) and hemodynamically unstable ventricular tachycardia (VT) in patients refractory to other therapy. Amiodarone Hydrochloride…
Full Amiodarone Hydrochloride guide →Digoxin Overview
DIGOXIN (brand name: Digoxin) is a Cardiac Glycosides. 1 INDICATIONS & USAGE Digoxin is a cardiac glycoside indicated for: Treatment of mild to moderate heart failure in adults. (1.1) Increasing myocardial contractility in pediatric patients with heart failure. (1.2) Control of resting ventricular rate in patients with chronic atrial fibrillation in…
Full Digoxin guide →How Each Drug Works
Amiodarone Hydrochloride
Amiodarone is generally considered a class III antiarrhythmic drug, but it possesses electrophysiologic characteristics of all four Vaughan Williams classes. Like class I drugs, amiodarone blocks sodium channels at rapid pacing frequencies, and like class II drugs, amiodarone exerts a noncompetitive antisympathetic action. One of its main effects, with prolonged administration, is to lengthen the cardiac action potential, a class III effect. The negative chronotropic eff…
Digoxin
All of digoxin’s actions are mediated through its effects on Na-K ATPase. This enzyme, the “sodium pump,” is responsible for maintaining the intracellular milieu throughout the body by moving sodium ions out of and potassium ions into cells. By inhibiting Na-K ATPase, digoxin causes increased availability of intracellular calcium in the myocardium and conduction system, with consequent increased inotropy, increased automaticity, and reduced conduction velocity indirectly…
Approved Uses (Indications)
Amiodarone Hydrochloride
Amiodarone Hydrochloride Injection, USP is indicated for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation (VF) and hemodynamically unstable ventricular tachycardia (VT) in patients refractory to other therapy. Amiodarone Hydrochloride Injection, USP also can be used to treat patients with VT/VF for whom oral amiodarone is indicated, but who are unable to take oral medication. During or after treatment with Amiodarone Hydrochloride Injection, USP patients may be transferred to oral amiodarone therapy [see Dosage and Administration …
Digoxin
Digoxin is a cardiac glycoside indicated for: Treatment of mild to moderate heart failure in adults. Increasing myocardial contractility in pediatric patients with heart failure. Control of resting ventricular rate in patients with chronic atrial fibrillation in adults. 1.1 Heart Failure in Adults Digoxin is indicated for the treatment of mild to moderate heart failure in adults. Digoxin increases left ventricular ejection fraction and improves heart failure symptoms as evidenced by improved exercise capacity and decreased heart failure-related hospitali…
Side Effects
Amiodarone Hydrochloride
Digoxin
Cost Comparison
Amiodarone Hydrochloride
$30-$80/month
Generic available
Generic amiodarone is widely available and generally affordable. Prices may vary based on pharmacy, dosage, and insurance coverage. Manufacturer coupons and patient assistance programs may be available.
Digoxin
$10-$50/month
Generic available
The cost of generic digoxin is relatively low, especially with insurance or discount coupons. Brand-name Lanoxin may be more expensive.
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