Combining Apixaban and Aspirin is a major interaction and should generally be avoided without close medical supervision.
Combining aspirin with apixaban significantly increases your risk of bleeding, including serious internal bleeding. Your doctor will weigh the benefits against this high risk.
Mechanism: Aspirin, particularly at higher doses, inhibits platelet aggregation and can cause gastrointestinal irritation. Apixaban directly inhibits Factor Xa, preventing clot formation. The concurrent use of these agents leads to a synergistic impairment of hemostasis, significantly increasing the risk of bleeding.
Apixaban vs. Aspirin
Compare Apixaban and Aspirin: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Apixaban
Eliquis
Anticoagulants
RxDrug B
Aspirin
Aspirin Regular Strength
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Apixaban | Aspirin |
|---|---|---|
| Drug Class | Anticoagulants | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $500–$700/month | $5–$20/month |
Apixaban Overview
Eliquis (apixaban) is a blood thinner medication used to help prevent harmful blood clots from forming in your body. It works by blocking a specific clotting factor, which reduces your risk of stroke if you have an irregular heartbeat (atrial fibrillation), or helps prevent and treat clots in your legs (DVT) and lungs (PE), especially after certain surgeries.
Full Apixaban guide →Aspirin Overview
ASPIRIN (brand name: Aspirin Regular Strength) is a NSAIDs. Uses temporarily relieves: headache muscle pain toothache menstrual pain pain and fever of colds minor pain of arthritis
Full Aspirin guide →How Each Drug Works
Apixaban
Apixaban is a selective inhibitor of FXa. It does not require antithrombin III for antithrombotic activity. Apixaban inhibits free and clot-bound FXa, and prothrombinase activity. Apixaban has no direct effect on platelet aggregation, but indirectly inhibits platelet aggregation induced by thrombin. By inhibiting FXa, apixaban decreases thrombin generation and thrombus development.
Approved Uses (Indications)
Apixaban
1 INDICATIONS AND USAGE ELIQUIS is a factor Xa inhibitor indicated:
- to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation.
- for the prophylaxis of deep vein thrombosis (DVT), which may lead to pulmonary embolism (PE), in patients who have undergone hip or knee replacement surgery.
- for the treatment of DVT and PE, and for the reduction in the risk of recurrent DVT and PE following initial therapy. 1.1 Reduction of Risk of Stroke and Systemic Embolism in Nonvalvular Atrial Fibrillation ELIQUIS is indicated to reduce…
Aspirin
Uses temporarily relieves: headache muscle pain toothache menstrual pain pain and fever of colds minor pain of arthritis
Side Effects
Apixaban
Cost Comparison
Apixaban
$500–$700/month
As a brand-name medication without a generic, Eliquis can be very expensive. Patients should look into manufacturer patient assistance programs or discount cards to help reduce costs.
Aspirin
$5–$20/month
Aspirin is available over-the-counter at a very low cost, often less than $5 for a large supply. Discount cards can sometimes offer minor savings on the prescription version, but it's generally more cost-effective to buy OTC.
Compare prices for Apixaban and Aspirin
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.