Combining Apixaban and Meloxicam is a major interaction and should generally be avoided without close medical supervision.
Combining meloxicam with apixaban significantly increases your risk of bleeding, especially from the stomach or intestines. This combination should generally be avoided due to the serious bleeding potential.
Mechanism: Meloxicam, a non-steroidal anti-inflammatory drug (NSAID), inhibits prostaglandin synthesis, which can impair gastric mucosal protection and inhibit platelet aggregation. Apixaban is a direct oral anticoagulant (DOAC) that inhibits Factor Xa, preventing clot formation. The concurrent use leads to additive antiplatelet and anticoagulant effects, alongside increased gastrointestinal mucosal damage from the NSAID.
Apixaban vs. Meloxicam
Compare Apixaban and Meloxicam: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Apixaban
Eliquis
Anticoagulants
RxDrug B
Meloxicam
meloxicam
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Apixaban | Meloxicam |
|---|---|---|
| Drug Class | Anticoagulants | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $500–$700/month | $4–$20/month |
Apixaban Overview
Eliquis (apixaban) is a blood thinner medication used to help prevent harmful blood clots from forming in your body. It works by blocking a specific clotting factor, which reduces your risk of stroke if you have an irregular heartbeat (atrial fibrillation), or helps prevent and treat clots in your legs (DVT) and lungs (PE), especially after certain surgeries.
Full Apixaban guide →Meloxicam Overview
MELOXICAM (brand name: meloxicam) is a NSAIDs. 1 INDICATIONS AND USAGE Meloxicam Tablets are non-steroidal anti-inflammatory drug indicated for: Osteoarthritis (OA) ( 1.1 ) Rheumatoid Arthritis (RA) ( 1.2 ) Juvenile Rheumatoid Arthritis (JRA) in patients who weigh ≥ 60 kg ( 1.3 ) 1.1 Osteoarthritis (OA) Meloxicam tablets are indicated for…
Full Meloxicam guide →How Each Drug Works
Apixaban
Apixaban is a selective inhibitor of FXa. It does not require antithrombin III for antithrombotic activity. Apixaban inhibits free and clot-bound FXa, and prothrombinase activity. Apixaban has no direct effect on platelet aggregation, but indirectly inhibits platelet aggregation induced by thrombin. By inhibiting FXa, apixaban decreases thrombin generation and thrombus development.
Meloxicam
Meloxicam has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of meloxicam, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Meloxicam is a potent inhibitor of prostaglandin synthesis in vitro . Meloxicam concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain i…
Approved Uses (Indications)
Apixaban
1 INDICATIONS AND USAGE ELIQUIS is a factor Xa inhibitor indicated:
- to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation.
- for the prophylaxis of deep vein thrombosis (DVT), which may lead to pulmonary embolism (PE), in patients who have undergone hip or knee replacement surgery.
- for the treatment of DVT and PE, and for the reduction in the risk of recurrent DVT and PE following initial therapy. 1.1 Reduction of Risk of Stroke and Systemic Embolism in Nonvalvular Atrial Fibrillation ELIQUIS is indicated to reduce…
Meloxicam
Meloxicam Tablets are non-steroidal anti-inflammatory drug indicated for: Osteoarthritis (OA) Rheumatoid Arthritis (RA) Juvenile Rheumatoid Arthritis (JRA) in patients who weigh ≥ 60 kg 1.1 Osteoarthritis (OA) Meloxicam tablets are indicated for relief of the signs and symptoms of osteoarthritis [see Clinical Studies ]. 1.2 Rheumatoid Arthritis (RA) Meloxicam tablets are indicated for relief of the signs and symptoms of rheumatoid arthritis [see Clinical Studies ].
Juvenile Rheumatoid Arthritis (JRA) Pauciarticular and Polya…
Side Effects
Apixaban
Meloxicam
Cost Comparison
Apixaban
$500–$700/month
As a brand-name medication without a generic, Eliquis can be very expensive. Patients should look into manufacturer patient assistance programs or discount cards to help reduce costs.
Meloxicam
$4–$20/month
Meloxicam is available as an inexpensive generic. Patients can significantly reduce costs using discount cards or by checking prices at different pharmacies.
Compare prices for Apixaban and Meloxicam
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.