Combining Apixaban and Piroxicam is a major interaction and should generally be avoided without close medical supervision.
Combining piroxicam, an anti-inflammatory pain reliever, with apixaban, a blood thinner, significantly increases your risk of serious bleeding, including stomach bleeding.
Mechanism: Piroxicam inhibits cyclooxygenase (COX) enzymes, leading to reduced prostaglandin synthesis and impaired platelet aggregation, which prolongs bleeding time. Apixaban directly inhibits Factor Xa, preventing thrombin generation and clot formation. The concurrent use results in additive antiplatelet and anticoagulant effects.
Apixaban vs. Piroxicam
Compare Apixaban and Piroxicam: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Apixaban
Eliquis
Anticoagulants
RxDrug B
Piroxicam
Piroxicam
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Apixaban | Piroxicam |
|---|---|---|
| Drug Class | Anticoagulants | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $500–$700/month | $10–$30/month |
Apixaban Overview
Eliquis (apixaban) is a blood thinner medication used to help prevent harmful blood clots from forming in your body. It works by blocking a specific clotting factor, which reduces your risk of stroke if you have an irregular heartbeat (atrial fibrillation), or helps prevent and treat clots in your legs (DVT) and lungs (PE), especially after certain surgeries.
Full Apixaban guide →Piroxicam Overview
PIROXICAM (brand name: Piroxicam) is a NSAIDs. 1 INDICATIONS AND USAGE Piroxicam capsules are indicated: • For relief of the signs and symptoms of osteoarthritis. • For relief of the signs and symptoms of rheumatoid arthritis. Piroxicam capsules are a nonsteroidal anti-inflammatory drug indicated for •Relief of the signs and symptoms of…
Full Piroxicam guide →How Each Drug Works
Apixaban
Apixaban is a selective inhibitor of FXa. It does not require antithrombin III for antithrombotic activity. Apixaban inhibits free and clot-bound FXa, and prothrombinase activity. Apixaban has no direct effect on platelet aggregation, but indirectly inhibits platelet aggregation induced by thrombin. By inhibiting FXa, apixaban decreases thrombin generation and thrombus development.
Piroxicam
Piroxicam has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of piroxicam capsules, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Piroxicam is a potent inhibitor of prostaglandin (PG) synthesis in vitro. Piroxicam concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in in…
Approved Uses (Indications)
Apixaban
1 INDICATIONS AND USAGE ELIQUIS is a factor Xa inhibitor indicated:
- to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation.
- for the prophylaxis of deep vein thrombosis (DVT), which may lead to pulmonary embolism (PE), in patients who have undergone hip or knee replacement surgery.
- for the treatment of DVT and PE, and for the reduction in the risk of recurrent DVT and PE following initial therapy. 1.1 Reduction of Risk of Stroke and Systemic Embolism in Nonvalvular Atrial Fibrillation ELIQUIS is indicated to reduce…
Piroxicam
Piroxicam capsules are indicated:
- For relief of the signs and symptoms of osteoarthritis.
- For relief of the signs and symptoms of rheumatoid arthritis. Piroxicam capsules are a nonsteroidal anti-inflammatory drug indicated for
- Relief of the signs and symptoms of osteoarthritis (OA)
- Relief of the signs and symptoms of rheumatoid arthritis (RA)
Side Effects
Apixaban
Piroxicam
Cost Comparison
Apixaban
$500–$700/month
As a brand-name medication without a generic, Eliquis can be very expensive. Patients should look into manufacturer patient assistance programs or discount cards to help reduce costs.
Piroxicam
$10–$30/month
Piroxicam is available as an affordable generic. Patients can often find significant savings by using discount cards or coupons from services like GoodRx.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.