Combining Argatroban and Diclofenac Sodium is a major interaction and should generally be avoided without close medical supervision.
Combining diclofenac with argatroban significantly increases your risk of bleeding, particularly from the stomach or intestines. This combination should generally be avoided.
Mechanism: Diclofenac, an NSAID, inhibits prostaglandin synthesis, which can impair gastric mucosal protection and inhibit platelet aggregation. Argatroban is a direct thrombin inhibitor, directly preventing clot formation. The combined effect of impaired platelet function and direct anticoagulation leads to a substantial increase in bleeding risk.
Argatroban vs. Diclofenac Sodium
Compare Argatroban and Diclofenac Sodium: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Argatroban
Argatroban
Anticoagulants
RxDrug B
Diclofenac Sodium
Diclofenac Sodium
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Argatroban | Diclofenac Sodium |
|---|---|---|
| Drug Class | Anticoagulants | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $500–$2,000/month | $10-$30/month |
Argatroban Overview
Argatroban is a medication that helps prevent and treat blood clots, especially in adults who have a condition called heparin-induced thrombocytopenia (HIT). It works by blocking a substance in the blood called thrombin, which is essential for clot formation, thereby keeping the blood from clotting too much. This also makes it useful as a blood thinner during certain heart procedures (like PCI) fo...
Full Argatroban guide →Diclofenac Sodium Overview
DICLOFENAC SODIUM (brand name: Diclofenac Sodium) is a NSAIDs. 1 INDICATIONS AND USAGE Diclofenac sodium topical solution, USP is indicated for the treatment of signs and symptoms of osteoarthritis of the knee(s) (1). Diclofenac sodium topical solution is a nonsteroidal anti-inflammatory drug indicated for the treatment of signs and symptoms of osteoarthritis…
Full Diclofenac Sodium guide →How Each Drug Works
Argatroban
Argatroban is a direct thrombin inhibitor that reversibly binds to the thrombin active site. Argatroban does not require the co-factor antithrombin III for antithrombotic activity. Argatroban exerts its anticoagulant effects by inhibiting thrombin-catalyzed or -induced reactions, including fibrin formation; activation of coagulation factors V, VIII, and XIII; activation of protein C; and platelet aggregation. Argatroban inhibits thrombin with an inhibition constant (Ki) …
Diclofenac Sodium
Diclofenac has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of diclofenac sodium, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Diclofenac is a potent inhibitor of prostaglandin synthesis in vitro. Diclofenac concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in induc…
Approved Uses (Indications)
Argatroban
Argatroban is a direct thrombin inhibitor indicated: For prophylaxis or treatment of thrombosis in adult patients with heparin-induced thrombocytopenia (HIT) As an anticoagulant in adult patients with or at risk for HIT undergoing percutaneous coronary intervention (PCI) 1.1 Heparin-Induced Thrombocytopenia Argatroban Injection is indicated for prophylaxis or treatment of thrombosis in adult patients with heparin-induced thrombocytopenia (HIT). 1.2 Percutaneous Coronary Intervention Argatroban Injection is indicated as an anticoagulant in adult patients …
Diclofenac Sodium
Diclofenac sodium topical solution, USP is indicated for the treatment of signs and symptoms of osteoarthritis of the knee(s) . Diclofenac sodium topical solution is a nonsteroidal anti-inflammatory drug indicated for the treatment of signs and symptoms of osteoarthritis of the knee(s).
Side Effects
Argatroban
Diclofenac Sodium
Cost Comparison
Argatroban
$500–$2,000/month
Argatroban is a brand-only, hospital-administered anticoagulant. Cost savings programs are typically not available for this type of medication.
Diclofenac Sodium
$10-$30/month
Diclofenac sodium is widely available as a low-cost generic. Patients can often find significant savings by using discount cards or pharmacy loyalty programs.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.