Combining Argatroban and Indomethacin is a major interaction and should generally be avoided without close medical supervision.
Combining indomethacin with argatroban significantly increases your risk of serious bleeding, including stomach bleeding. This combination should generally be avoided.
Mechanism: Indomethacin, a non-selective NSAID, inhibits cyclooxygenase (COX-1 and COX-2) enzymes, leading to reduced prostaglandin synthesis. This impairs platelet aggregation and damages the gastrointestinal mucosal barrier. Argatroban is a direct thrombin inhibitor, which directly interferes with the coagulation cascade, prolonging clotting times. The combined antiplatelet effect of indomethacin and the anticoagulant effect of argatroban lead to a synergistic increase in bleeding risk.
Argatroban vs. Indomethacin
Compare Argatroban and Indomethacin: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Argatroban
Argatroban
Anticoagulants
RxDrug B
Indomethacin
Indomethacin
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Argatroban | Indomethacin |
|---|---|---|
| Drug Class | Anticoagulants | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $500–$2,000/month | $30–$80/month |
Argatroban Overview
Argatroban is a medication that helps prevent and treat blood clots, especially in adults who have a condition called heparin-induced thrombocytopenia (HIT). It works by blocking a substance in the blood called thrombin, which is essential for clot formation, thereby keeping the blood from clotting too much. This also makes it useful as a blood thinner during certain heart procedures (like PCI) fo...
Full Argatroban guide →Indomethacin Overview
INDOMETHACIN (brand name: Indomethacin) is a NSAIDs. INDICATIONS AND USAGE Carefully consider the potential benefits and risks of indomethacin capsules and other treatment options before deciding to use indomethacin. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS ).…
Full Indomethacin guide →How Each Drug Works
Argatroban
Argatroban is a direct thrombin inhibitor that reversibly binds to the thrombin active site. Argatroban does not require the co-factor antithrombin III for antithrombotic activity. Argatroban exerts its anticoagulant effects by inhibiting thrombin-catalyzed or -induced reactions, including fibrin formation; activation of coagulation factors V, VIII, and XIII; activation of protein C; and platelet aggregation. Argatroban inhibits thrombin with an inhibition constant (Ki) …
Approved Uses (Indications)
Argatroban
Argatroban is a direct thrombin inhibitor indicated: For prophylaxis or treatment of thrombosis in adult patients with heparin-induced thrombocytopenia (HIT) As an anticoagulant in adult patients with or at risk for HIT undergoing percutaneous coronary intervention (PCI) 1.1 Heparin-Induced Thrombocytopenia Argatroban Injection is indicated for prophylaxis or treatment of thrombosis in adult patients with heparin-induced thrombocytopenia (HIT). 1.2 Percutaneous Coronary Intervention Argatroban Injection is indicated as an anticoagulant in adult patients …
Indomethacin
INDICATIONS AND USAGE Carefully consider the potential benefits and risks of indomethacin capsules and other treatment options before deciding to use indomethacin. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS ). Indomethacin Capsule, USP has been found effective in active stages of the following: Moderate to severe rheumatoid arthritis including acute flares of chronic disease. Moderate to severe ankylosing spondylitis. Moderate to severe osteoarthritis. Acute painful shoulder (bursitis and/or tendinitis). Acute gouty …
Side Effects
Argatroban
Indomethacin
Cost Comparison
Argatroban
$500–$2,000/month
Argatroban is a brand-only, hospital-administered anticoagulant. Cost savings programs are typically not available for this type of medication.
Indomethacin
$30–$80/month
While Indomethacin is available generically, its brand name is also Indomethacin. Using discount cards like GoodRx can often help reduce the cost significantly.
Compare prices for Argatroban and Indomethacin
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.