Combining Aspirin 81 mg and Indomethacin is a major interaction and should generally be avoided without close medical supervision.
Combining indomethacin with aspirin 81 mg significantly increases your risk of bleeding, particularly in the stomach and intestines. This combination should generally be avoided.
Mechanism: Both indomethacin (an NSAID) and aspirin (an antiplatelet) inhibit platelet aggregation, though through different mechanisms. Indomethacin reversibly inhibits cyclooxygenase (COX) enzymes, reducing thromboxane A2 production, while aspirin irreversibly inhibits COX-1. Their combined antiplatelet effects are additive, leading to a synergistic increase in bleeding tendency.
Aspirin 81 mg vs. Indomethacin
Compare Aspirin 81 mg and Indomethacin: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Aspirin 81 mg
Aspirin Enteric Coated
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxDrug B
Indomethacin
Indomethacin
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Aspirin 81 mg | Indomethacin |
|---|---|---|
| Drug Class | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $5–$20/month | $30–$80/month |
Aspirin 81 mg Overview
ASPIRIN 81 MG (brand name: Aspirin Enteric Coated) is a NSAIDs. Use(s) for the temporary relief of minor aches and pain or as recommended by your doctor. Because of its delayed action, this product will not provide fast relief of headaches or other symptoms needing immediate relief.
Full Aspirin 81 mg guide →Indomethacin Overview
INDOMETHACIN (brand name: Indomethacin) is a NSAIDs. INDICATIONS AND USAGE Carefully consider the potential benefits and risks of indomethacin capsules and other treatment options before deciding to use indomethacin. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS ).…
Full Indomethacin guide →Approved Uses (Indications)
Aspirin 81 mg
Use(s) for the temporary relief of minor aches and pain or as recommended by your doctor. Because of its delayed action, this product will not provide fast relief of headaches or other symptoms needing immediate relief.
Indomethacin
INDICATIONS AND USAGE Carefully consider the potential benefits and risks of indomethacin capsules and other treatment options before deciding to use indomethacin. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS ). Indomethacin Capsule, USP has been found effective in active stages of the following: Moderate to severe rheumatoid arthritis including acute flares of chronic disease. Moderate to severe ankylosing spondylitis. Moderate to severe osteoarthritis. Acute painful shoulder (bursitis and/or tendinitis). Acute gouty …
Side Effects
Indomethacin
Cost Comparison
Aspirin 81 mg
$5–$20/month
Despite being a brand, Aspirin 81 mg is very inexpensive. Look for store brand or generic aspirin for even lower prices, and discount cards can often reduce the cost further.
Indomethacin
$30–$80/month
While Indomethacin is available generically, its brand name is also Indomethacin. Using discount cards like GoodRx can often help reduce the cost significantly.
Compare prices for Aspirin 81 mg and Indomethacin
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.