Combining Aspirin 81 mg and Ketorolac Tromethamine is a major interaction and should generally be avoided without close medical supervision.
Combining ketorolac with aspirin significantly increases your risk of bleeding, especially in the stomach or intestines. This combination should generally be avoided due to the high risk.
Mechanism: Ketorolac, a non-selective NSAID, inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin synthesis and impairing platelet aggregation. Aspirin 81mg also irreversibly inhibits COX-1, leading to reduced thromboxane A2 production and antiplatelet effects. The concurrent use of two agents with antiplatelet activity creates an additive effect, profoundly increasing the risk of bleeding.
Aspirin 81 mg vs. Ketorolac Tromethamine
Compare Aspirin 81 mg and Ketorolac Tromethamine: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Aspirin 81 mg
Aspirin Enteric Coated
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxDrug B
Ketorolac Tromethamine
Ketorolac Tromethamine
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Aspirin 81 mg | Ketorolac Tromethamine |
|---|---|---|
| Drug Class | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $5–$20/month | $10–$50/month |
Aspirin 81 mg Overview
ASPIRIN 81 MG (brand name: Aspirin Enteric Coated) is a NSAIDs. Use(s) for the temporary relief of minor aches and pain or as recommended by your doctor. Because of its delayed action, this product will not provide fast relief of headaches or other symptoms needing immediate relief.
Full Aspirin 81 mg guide →Ketorolac Tromethamine Overview
KETOROLAC TROMETHAMINE (brand name: Ketorolac Tromethamine) is a NSAIDs. INDICATIONS AND USAGE Carefully consider the potential benefits and risks of Ketorolac Tromethamine Tablets USP and other treatment options before deciding to use Ketorolac Tromethamine Tablets USP. Use the lowest effective dose for the shortest duration consistent with individual patient treatment…
Full Ketorolac Tromethamine guide →Approved Uses (Indications)
Aspirin 81 mg
Use(s) for the temporary relief of minor aches and pain or as recommended by your doctor. Because of its delayed action, this product will not provide fast relief of headaches or other symptoms needing immediate relief.
Ketorolac Tromethamine
INDICATIONS AND USAGE Carefully consider the potential benefits and risks of Ketorolac Tromethamine Tablets USP and other treatment options before deciding to use Ketorolac Tromethamine Tablets USP. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals. Acute Pain in Adult Patients Ketorolac Tromethamine Tablets USP are indicated for the short-term (≤ 5 days) management of moderately severe acute pain that requires analgesia at the opioid level, usually in a postoperative setting. Therapy should always be initiated with IV or IM dosing of ke…
Side Effects
Ketorolac Tromethamine
Cost Comparison
Aspirin 81 mg
$5–$20/month
Despite being a brand, Aspirin 81 mg is very inexpensive. Look for store brand or generic aspirin for even lower prices, and discount cards can often reduce the cost further.
Ketorolac Tromethamine
$10–$50/month
As a widely available generic, Ketorolac Tromethamine is typically inexpensive. Using discount cards like GoodRx can often reduce the cost further to just a few dollars per month.
Compare prices for Aspirin 81 mg and Ketorolac Tromethamine
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.