Combining Aspirin 81 mg and Naproxen is a major interaction and should generally be avoided without close medical supervision.
Combining naproxen with aspirin 81mg significantly increases your risk of bleeding, especially in the stomach and intestines. This combination should generally be avoided unless specifically directed and closely monitored by your doctor.
Mechanism: Naproxen, a non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis and impairing platelet aggregation. Aspirin 81mg is an antiplatelet agent that irreversibly inhibits COX-1, preventing thromboxane A2 formation and platelet aggregation. The concurrent use of both drugs results in additive antiplatelet effects and increased gastrointestinal mucosal damage, leading to a synergistic increase in bleeding risk.
Aspirin 81 mg vs. Naproxen
Compare Aspirin 81 mg and Naproxen: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Aspirin 81 mg
Aspirin Enteric Coated
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxDrug B
Naproxen
Naproxen
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Aspirin 81 mg | Naproxen |
|---|---|---|
| Drug Class | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $5–$20/month | $4–$25/month |
Aspirin 81 mg Overview
ASPIRIN 81 MG (brand name: Aspirin Enteric Coated) is a NSAIDs. Use(s) for the temporary relief of minor aches and pain or as recommended by your doctor. Because of its delayed action, this product will not provide fast relief of headaches or other symptoms needing immediate relief.
Full Aspirin 81 mg guide →Naproxen Overview
NAPROXEN (brand name: Naproxen) is a NSAIDs. 1 INDICATIONS & USAGE Naproxen delayed-release tablets are indicated for: the relief of the signs and symptoms of: rheumatoid arthritis osteoarthritis ankylosing spondylitis Polyarticular Juvenile Idiopathic Arthritis Naproxen delayed-release tablets are non-steroidal anti-inflammatory drugs…
Full Naproxen guide →How Each Drug Works
Naproxen
Naproxen has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of naproxen, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Naproxen is a potent inhibitor of prostaglandin synthesis in vitro. Naproxen concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in ani…
Approved Uses (Indications)
Aspirin 81 mg
Use(s) for the temporary relief of minor aches and pain or as recommended by your doctor. Because of its delayed action, this product will not provide fast relief of headaches or other symptoms needing immediate relief.
Naproxen
Naproxen delayed-release tablets are indicated for: the relief of the signs and symptoms of: rheumatoid arthritis osteoarthritis ankylosing spondylitis Polyarticular Juvenile Idiopathic Arthritis Naproxen delayed-release tablets are non-steroidal anti-inflammatory drugs indicated for: the relief of the signs and symptoms of: rheumatoid arthritis osteoarthritis ankylosing spondylitis polyarticular juvenile idiopathic arthritis
Side Effects
Naproxen
Cost Comparison
Aspirin 81 mg
$5–$20/month
Despite being a brand, Aspirin 81 mg is very inexpensive. Look for store brand or generic aspirin for even lower prices, and discount cards can often reduce the cost further.
Naproxen
$4–$25/month
Naproxen is widely available as an affordable generic. Using discount cards like GoodRx can further reduce the cost, often bringing it to under $10 per month.
Compare prices for Aspirin 81 mg and Naproxen
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.