Combining Aspirin and Ticagrelor is a major interaction and should generally be avoided without close medical supervision.
Combining aspirin and ticagrelor significantly increases your risk of bleeding, especially in the stomach and intestines. Your doctor will carefully weigh the benefits against this increased risk.
Mechanism: Aspirin, even at low doses, inhibits platelet aggregation irreversibly by blocking cyclooxygenase-1 (COX-1), reducing thromboxane A2 production. Ticagrelor is a direct-acting, reversible P2Y12 platelet inhibitor. The concurrent use of two antiplatelet agents results in additive antiplatelet effects, severely impairing the body's ability to form clots.
Aspirin vs. Ticagrelor
Compare Aspirin and Ticagrelor: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Aspirin
Aspirin Regular Strength
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxDrug B
Ticagrelor
Ticagrelor
Antiplatelet Agents
RxQuick Comparison
| Category | Aspirin | Ticagrelor |
|---|---|---|
| Drug Class | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) | Antiplatelet Agents |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $5–$20/month | $400–$700/month |
Aspirin Overview
ASPIRIN (brand name: Aspirin Regular Strength) is a NSAIDs. Uses temporarily relieves: headache muscle pain toothache menstrual pain pain and fever of colds minor pain of arthritis
Full Aspirin guide →Ticagrelor Overview
Ticagrelor is an anti-platelet medication that helps prevent blood clots. It works by making your platelets (tiny blood cells involved in clotting) less sticky, reducing the risk of serious heart problems like heart attacks and strokes, especially in people with acute coronary syndrome or a history of heart disease.
Full Ticagrelor guide →How Each Drug Works
Ticagrelor
Ticagrelor and its major metabolite reversibly interact with the platelet P2Y 12 ADP-receptor to prevent signal transduction and platelet activation. Ticagrelor and its active metabolite are approximately equipotent.
Approved Uses (Indications)
Aspirin
Uses temporarily relieves: headache muscle pain toothache menstrual pain pain and fever of colds minor pain of arthritis
Ticagrelor
Ticagrelor tablets are a P2Y 12 platelet inhibitor indicated
- to reduce the risk of cardiovascular (CV) death, myocardial infarction (MI), and stroke in patients with acute coronary syndrome (ACS) or a history of MI. For at least the first 12 months following ACS, it is superior to clopidogrel. Ticagrelor tablets also reduce the risk of stent thrombosis in patients who have been stented for treatment of ACS.
- to reduce the risk of a first MI or stroke in patients with coronary artery disease (CAD) at high risk for such events. While use is not limited to this …
Side Effects
Ticagrelor
Cost Comparison
Aspirin
$5–$20/month
Aspirin is available over-the-counter at a very low cost, often less than $5 for a large supply. Discount cards can sometimes offer minor savings on the prescription version, but it's generally more cost-effective to buy OTC.
Ticagrelor
$400–$700/month
As a brand-name medication, Ticagrelor can be expensive. Patients should look for manufacturer patient assistance programs or discount cards like GoodRx to help reduce the cost.
Compare prices for Aspirin and Ticagrelor
Check real-time pharmacy prices before you fill — free, no account needed.
Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.