Combining Baclofen and Hydromorphone Hydrochloride is a major interaction and should generally be avoided without close medical supervision.
The concurrent use of hydromorphone and baclofen significantly increases the risk of severe CNS depression, including profound sedation, respiratory depression, coma, and even death. Patients may experience impaired psychomotor function, dizziness, confusion, and hypotension.
Mechanism: Hydromorphone, an opioid agonist, produces central nervous system (CNS) depression by binding to mu-opioid receptors. Baclofen, a GABA-B receptor agonist, also causes CNS depression by inhibiting neuronal activity in the spinal cord and brain. The co-administration of these agents results in an additive depressant effect on the CNS.
Baclofen vs. Hydromorphone Hydrochloride
Compare Baclofen and Hydromorphone Hydrochloride: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Baclofen
Baclofen (Intrathecal)
Skeletal Muscle Relaxants
RxDrug B
Hydromorphone Hydrochloride
Hydromorphone Hydrochloride
Opioid Analgesics
RxQuick Comparison
| Category | Baclofen | Hydromorphone Hydrochloride |
|---|---|---|
| Drug Class | Skeletal Muscle Relaxants | Opioid Analgesics |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $1,500–$5,000+/month | $200–$500/month |
Baclofen Overview
Baclofen (Intrathecal) is a medication delivered directly into the fluid surrounding your spinal cord to help manage severe muscle stiffness and spasms, known as spasticity. It works by relaxing your muscles, which can improve movement and reduce discomfort caused by conditions like spinal cord injury or multiple sclerosis. This treatment is typically used when other baclofen forms haven't been ef...
Full Baclofen guide →Hydromorphone Hydrochloride Overview
HYDROMORPHONE HYDROCHLORIDE (brand name: Hydromorphone Hydrochloride) is a Opioid Analgesics. INDICATIONS AND USAGE Hydromorphone Hydrochloride Injection is indicated for the relief of moderate to severe pain such as that due to: surgery, cancer, trauma (soft tissue and bone), biliary colic, myocardial infarction, burns, renal colic.
Full Hydromorphone Hydrochloride guide →Approved Uses (Indications)
Baclofen
INDICATIONS AND USAGE Baclofen injection (intrathecal) is indicated for use in the management of severe spasticity. Patients should first respond to a screening dose of intrathecal baclofen prior to consideration for long term infusion via an implantable pump. For spasticity of spinal cord origin, chronic infusion of baclofen injection (intrathecal) via an implantable pump should be reserved for patients unresponsive to oral baclofen therapy, or those who experience intolerable CNS side effects at effective doses. Patients with spasticity due to traumatic brain injury should wait at least one …
Hydromorphone Hydrochloride
INDICATIONS AND USAGE Hydromorphone Hydrochloride Injection is indicated for the relief of moderate to severe pain such as that due to: surgery, cancer, trauma (soft tissue and bone), biliary colic, myocardial infarction, burns, renal colic.
Side Effects
Baclofen
Hydromorphone Hydrochloride
Cost Comparison
Baclofen
$1,500–$5,000+/month
As this is a brand-only, specialty medication, costs can be very high. Explore manufacturer patient assistance programs or speak with your doctor about potential financial aid options.
Hydromorphone Hydrochloride
$200–$500/month
As a brand-only medication, costs without insurance can be high. Discuss patient assistance programs with your doctor or pharmacist for potential savings.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.