Combining Bivalirudin and Ketorolac Tromethamine is a major interaction and should generally be avoided without close medical supervision.
Combining ketorolac (an NSAID) with bivalirudin (an anticoagulant) significantly increases your risk of serious bleeding, including internal bleeding. This combination should generally be avoided.
Mechanism: Ketorolac inhibits cyclooxygenase enzymes, reducing prostaglandin synthesis and impairing platelet aggregation. Bivalirudin is a direct thrombin inhibitor that prevents fibrin formation and thrombus growth. The concurrent use of these agents results in additive antihemostatic effects, significantly increasing the risk of bleeding.
Bivalirudin vs. Ketorolac Tromethamine
Compare Bivalirudin and Ketorolac Tromethamine: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Bivalirudin
Bivalirudin
Anticoagulants
RxDrug B
Ketorolac Tromethamine
Ketorolac Tromethamine
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Bivalirudin | Ketorolac Tromethamine |
|---|---|---|
| Drug Class | Anticoagulants | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $1,000–$3,000/dose | $10–$50/month |
Bivalirudin Overview
Bivalirudin is an anticoagulant medication that helps prevent blood clots. It works by directly blocking a substance in the blood called thrombin, which is essential for clot formation. This medication is primarily used during a heart procedure called percutaneous coronary intervention (PCI), especially for patients who cannot use heparin due to a specific blood condition.
Full Bivalirudin guide →Ketorolac Tromethamine Overview
KETOROLAC TROMETHAMINE (brand name: Ketorolac Tromethamine) is a NSAIDs. INDICATIONS AND USAGE Carefully consider the potential benefits and risks of Ketorolac Tromethamine Tablets USP and other treatment options before deciding to use Ketorolac Tromethamine Tablets USP. Use the lowest effective dose for the shortest duration consistent with individual patient treatment…
Full Ketorolac Tromethamine guide →How Each Drug Works
Bivalirudin
Bivalirudin directly inhibits thrombin by specifically binding both to the catalytic site and to the anion-binding exosite of circulating and clot-bound thrombin. Thrombin is a serine proteinase that plays a central role in the thrombotic process, acting to cleave fibrinogen into fibrin monomers and to activate Factor XIII to Factor XIIIa, allowing fibrin to develop a covalently cross-linked framework which stabilizes the thrombus; thrombin also activates Factors V and V…
Approved Uses (Indications)
Bivalirudin
Bivalirudin for injection is indicated for use as an anticoagulant for use in patients undergoing percutaneous coronary intervention (PCI) including patients with heparin-induced thrombocytopenia and heparin-induced thrombocytopenia and thrombosis syndrome. Bivalirudin for injection is a direct thrombin inhibitor indicated for use as an anticoagulant in patients undergoing percutaneous coronary intervention (PCI) including patients with heparin-induced thrombocytopenia (HIT) or heparin-induced thrombocytopenia and thrombosis syndrome (HITTS).
Ketorolac Tromethamine
INDICATIONS AND USAGE Carefully consider the potential benefits and risks of Ketorolac Tromethamine Tablets USP and other treatment options before deciding to use Ketorolac Tromethamine Tablets USP. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals. Acute Pain in Adult Patients Ketorolac Tromethamine Tablets USP are indicated for the short-term (≤ 5 days) management of moderately severe acute pain that requires analgesia at the opioid level, usually in a postoperative setting. Therapy should always be initiated with IV or IM dosing of ke…
Side Effects
Bivalirudin
Ketorolac Tromethamine
Cost Comparison
Bivalirudin
$1,000–$3,000/dose
Bivalirudin is typically administered in a hospital setting, so the cost is often covered as part of the overall procedure or hospitalization bill rather than as a separate retail prescription. Patient assistance programs might be available for specific outpatient uses, but retail coupons are generally not applicable.
Ketorolac Tromethamine
$10–$50/month
As a widely available generic, Ketorolac Tromethamine is typically inexpensive. Using discount cards like GoodRx can often reduce the cost further to just a few dollars per month.
Compare prices for Bivalirudin and Ketorolac Tromethamine
Check real-time pharmacy prices before you fill — free, no account needed.
Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.