Combining Buprenorphine and Tizanidine is a major interaction and should generally be avoided without close medical supervision.
Patients may experience increased sedation, somnolence, dizziness, and psychomotor impairment. The most serious clinical effect is an enhanced risk of respiratory depression, which can be life-threatening. Other effects include hypotension and profound bradycardia.
Mechanism: Buprenorphine, a partial opioid agonist, exerts its analgesic and CNS depressant effects primarily through mu-opioid receptor agonism. Tizanidine, an alpha-2 adrenergic agonist, reduces spasticity by increasing presynaptic inhibition of motor neurons in the spinal cord, which also leads to CNS depression. The co-administration of these two agents results in additive CNS depression.
Buprenorphine vs. Tizanidine
Compare Buprenorphine and Tizanidine: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Buprenorphine
Buprenorphine
Opioid Analgesics
RxDrug B
Tizanidine
Tizanidine
Skeletal Muscle Relaxants
RxQuick Comparison
| Category | Buprenorphine | Tizanidine |
|---|---|---|
| Drug Class | Opioid Analgesics | Skeletal Muscle Relaxants |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $50–$300/month | $4–$25/month |
Buprenorphine Overview
BUPRENORPHINE (brand name: BUPRENORPHINE) is a Opioid Analgesics. 1 INDICATIONS AND USAGE Buprenorphine Sublingual Tablets are indicated for the treatment of opioid dependence and are preferred for induction. Buprenorphine sublingual tablets should be used as part of a complete treatment plan to include counseling and psychosocial support. Buprenorphine…
Full Buprenorphine guide →Tizanidine Overview
Tizanidine is a medication used to relax muscles and reduce muscle stiffness or spasms (spasticity). It works by acting on the nervous system to calm overactive nerve signals that cause muscles to tighten. This helps improve muscle movement and comfort for daily activities.
Full Tizanidine guide →How Each Drug Works
Buprenorphine
Buprenorphine sublingual tablets contain buprenorphine, a partial agonist at the mu-opioid receptor and an antagonist at the kappa-opioid receptor.
Tizanidine
Tizanidine is a central alpha-2-adrenergic receptor agonist and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. The effects of tizanidine are greatest on polysynaptic pathways. The effect of these actions is thought to reduce facilitation of spinal motor neurons.
Approved Uses (Indications)
Buprenorphine
Buprenorphine Sublingual Tablets are indicated for the treatment of opioid dependence and are preferred for induction. Buprenorphine sublingual tablets should be used as part of a complete treatment plan to include counseling and psychosocial support. Buprenorphine sublingual tablets contain buprenorphine, a partial opioid agonist, and are indicated for the treatment of opioid dependence and are preferred for induction. Buprenorphine sublingual tablets should be used as part of a complete treatment plan that includes counseling and psychosocial support.
Tizanidine
Tizanidine Tablets, USP is a central alpha-2-adrenergic agonist indicated for the management of spasticity. Because of the short duration of therapeutic effect, treatment with Tizanidine Tablets, USP should be reserved for those daily activities and times when relief of spasticity is most important [see Dosage and Administration ]. Tizanidine Tablets, USP is a central alpha-2-adrenergic agonist indicated for the management of spasticity. Because of the short duration of therapeutic effect, treatment with Tizanidine Tablets, USP should be reserved for those daily ac…
Side Effects
Buprenorphine
Tizanidine
Cost Comparison
Buprenorphine
$50–$300/month
While Buprenorphine is available as a generic, prices can vary significantly depending on the specific formulation and dosage. Using discount cards like GoodRx can often help reduce the out-of-pocket cost.
Tizanidine
$4–$25/month
Tizanidine is available as an affordable generic. Patients can often find significant savings by using discount cards like GoodRx or checking prices at different pharmacies.
Compare prices for Buprenorphine and Tizanidine
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.