Combining Carvedilol and Fluoxetine is a major interaction and should generally be avoided without close medical supervision.
Fluoxetine is a potent inhibitor of CYP2D6, which is a primary enzyme responsible for the metabolism of carvedilol. This inhibition can lead to significantly increased plasma concentrations of carvedilol, raising the risk of adverse effects such as severe bradycardia, hypotension, and heart block.
Mechanism: Fluoxetine inhibits the cytochrome P450 2D6 (CYP2D6) enzyme. Carvedilol is metabolized by CYP2D6, so fluoxetine reduces carvedilol's metabolism, increasing its systemic exposure and pharmacodynamic effects.
Carvedilol vs. Fluoxetine
Compare Carvedilol and Fluoxetine: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Carvedilol
Carvedilol
Beta-Blockers
RxDrug B
Fluoxetine
Fluoxetine
SSRIs (Selective Serotonin Reuptake Inhibitors)
RxQuick Comparison
| Category | Carvedilol | Fluoxetine |
|---|---|---|
| Drug Class | Beta-Blockers | SSRIs (Selective Serotonin Reuptake Inhibitors) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $4-$25/month | $4–$15/month |
Carvedilol Overview
Carvedilol is a medication known as an alpha and beta blocker. It is prescribed to treat conditions such as high blood pressure, chronic heart failure, and to improve outcomes after a heart attack. Carvedilol works by relaxing blood vessels and slowing the heart rate, which helps the heart pump blood more easily and efficiently.
Full Carvedilol guide →Fluoxetine Overview
Fluoxetine is a type of antidepressant medication called a selective serotonin reuptake inhibitor (SSRI). It is used to treat conditions like depression, obsessive-compulsive disorder (OCD), bulimia nervosa, and panic disorder by helping to restore the balance of a natural substance called serotonin in the brain.
Full Fluoxetine guide →How Each Drug Works
Carvedilol
Carvedilol is a racemic mixture in which nonselective β-adrenoreceptor blocking activity is present in the S(-) enantiomer and α 1 -adrenergic blocking activity is present in both R(+) and S(-) enantiomers at equal potency. Carvedilol has no intrinsic sympathomimetic activity.
Fluoxetine
Although the exact mechanism of fluoxetine is unknown, it is presumed to be linked to its inhibition of CNS neuronal uptake of serotonin.
Approved Uses (Indications)
Carvedilol
Carvedilol tablets are an alpha-/beta-adrenergic blocking agent indicated for the treatment of: mild to severe chronic heart failure left ventricular dysfunction following myocardial infarction in clinically stable patients hypertension 1.1 Heart Failure Carvedilol tablets are indicated for the treatment of mild-to-severe chronic heart failure of ischemic or cardiomyopathic origin, usually in addition to diuretics, ACE inhibitors, and digitalis, to increase survival and, also, to reduce the risk of hospitalization [see Drug Interactions , …
Fluoxetine
Fluoxetine is a a selective serotonin reuptake inhibitor indicated for: Acute and maintenance treatment of Major Depressive Disorder (MDD) in adult and pediatric patients aged 8 to 18 years Acute and maintenance treatment of Obsessive Compulsive Disorder (OCD) in adults and pediatric patients aged 7 to 17 years Acute and maintenance treatment of Bulimia Nervosa in adult patients Acute treatment of Panic Disorder, with or without agoraphobia, in adult patients 1.1 Major Depressive Disorder Fluoxetine tablets are indicated for the acute and mainten…
Side Effects
Carvedilol
Fluoxetine
Cost Comparison
Carvedilol
$4-$25/month
As a widely available generic, Carvedilol is typically inexpensive. Using discount cards or pharmacy loyalty programs can further reduce the cost.
Fluoxetine
$4–$15/month
As a widely available generic, Fluoxetine is very affordable. Patients can often find significant savings by using discount cards like GoodRx or checking prices at different pharmacies.
Compare prices for Carvedilol and Fluoxetine
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.