Combining Carvedilol and Metoprolol Tartrate is a major interaction and should generally be avoided without close medical supervision.
Combining metoprolol and carvedilol, both beta-blockers, can lead to an additive effect, significantly increasing the risk of bradycardia, hypotension, and heart failure exacerbation. This combination is generally not recommended due to the heightened risk of adverse cardiovascular events.
Mechanism: Both metoprolol and carvedilol exert their primary therapeutic effects by blocking beta-adrenergic receptors, leading to decreased heart rate, myocardial contractility, and blood pressure. Their co-administration results in an enhanced pharmacodynamic effect, increasing the likelihood of profound beta-blockade.
Carvedilol vs. Metoprolol Tartrate
Compare Carvedilol and Metoprolol Tartrate: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Carvedilol
Carvedilol
Beta-Blockers
RxDrug B
Metoprolol Tartrate
Metoprolol Tartrate
Beta-Blockers
RxQuick Comparison
| Category | Carvedilol | Metoprolol Tartrate |
|---|---|---|
| Drug Class | Beta-Blockers | Beta-Blockers |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $4-$25/month | $4–$25/month |
Carvedilol Overview
Carvedilol is a medication known as an alpha and beta blocker. It is prescribed to treat conditions such as high blood pressure, chronic heart failure, and to improve outcomes after a heart attack. Carvedilol works by relaxing blood vessels and slowing the heart rate, which helps the heart pump blood more easily and efficiently.
Full Carvedilol guide →Metoprolol Tartrate Overview
Metoprolol Tartrate is a beta-blocker medication used to treat high blood pressure, chest pain (angina), and to improve outcomes after a heart attack. It works by relaxing blood vessels and slowing the heart rate, which helps to lower blood pressure and reduce the heart's workload.
Full Metoprolol Tartrate guide →How Each Drug Works
Carvedilol
Carvedilol is a racemic mixture in which nonselective β-adrenoreceptor blocking activity is present in the S(-) enantiomer and α 1 -adrenergic blocking activity is present in both R(+) and S(-) enantiomers at equal potency. Carvedilol has no intrinsic sympathomimetic activity.
Approved Uses (Indications)
Carvedilol
Carvedilol tablets are an alpha-/beta-adrenergic blocking agent indicated for the treatment of: mild to severe chronic heart failure left ventricular dysfunction following myocardial infarction in clinically stable patients hypertension 1.1 Heart Failure Carvedilol tablets are indicated for the treatment of mild-to-severe chronic heart failure of ischemic or cardiomyopathic origin, usually in addition to diuretics, ACE inhibitors, and digitalis, to increase survival and, also, to reduce the risk of hospitalization [see Drug Interactions , …
Metoprolol Tartrate
Metoprolol tartrate is a beta-adrenergic blocker indicated for the treatment of:
- Hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions.
- Angina Pectoris.
- Myocardial Infarction, to reduce the risk of cardiovascular mortality when used in conjunction with intravenous metoprolol therapy in patients with definite or suspected acute myocardial infarction in hemodynamically stable patients.
Hypertension Metoprolol tartrate is in…
Side Effects
Carvedilol
Metoprolol Tartrate
Cost Comparison
Carvedilol
$4-$25/month
As a widely available generic, Carvedilol is typically inexpensive. Using discount cards or pharmacy loyalty programs can further reduce the cost.
Metoprolol Tartrate
$4–$25/month
As a widely available generic, Metoprolol Tartrate is typically affordable. Using discount cards like GoodRx can further reduce the cost, often bringing it down to under $10 per month at many pharmacies.
Compare prices for Carvedilol and Metoprolol Tartrate
Check real-time pharmacy prices before you fill — free, no account needed.
Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.