Combining Celecoxib and Clopidogrel is a major interaction and should generally be avoided without close medical supervision.
Combining celecoxib with clopidogrel significantly increases your risk of bleeding, especially in the stomach or intestines. You should avoid taking these medications together unless specifically directed by your doctor.
Mechanism: Celecoxib, an NSAID, inhibits prostaglandin synthesis, which can impair gastric mucosal defense and platelet aggregation. Clopidogrel is an antiplatelet agent that irreversibly inhibits the P2Y12 ADP receptor on platelets, preventing platelet activation and aggregation. The combined antiplatelet effects and gastric irritation from celecoxib lead to an additive increase in bleeding risk.
Celecoxib vs. Clopidogrel
Compare Celecoxib and Clopidogrel: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Celecoxib
celecoxib
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxDrug B
Clopidogrel
Clopidogrel
Antiplatelet Agents
RxQuick Comparison
| Category | Celecoxib | Clopidogrel |
|---|---|---|
| Drug Class | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) | Antiplatelet Agents |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $150–$400/month | $10–$30/month |
Celecoxib Overview
CELECOXIB (brand name: celecoxib) is a NSAIDs. 1 INDICATIONS AND USAGE Celecoxib capsules are indicated Celecoxib capsules are a nonsteroidal anti-inflammatory drug indicated for: • Osteoarthritis (OA) ( 1.1 ) • Rheumatoid Arthritis (RA) ( 1.2 ) • Juvenile Rheumatoid Arthritis (JRA) in patients 2 years and older ( 1.3 ) • Ankylosing Spondylitis…
Full Celecoxib guide →Clopidogrel Overview
CLOPIDOGREL (brand name: Clopidogrel) is a Antiplatelet Agents. 1 INDICATIONS & USAGE Clopidogrel is a P2Y 12 platelet inhibitor indicated for: • Acute coronary syndrome - For patients with non-ST-segment elevation ACS (unstable angina [UA]/non-ST-elevation myocardial infarction [NSTEMI]), clopidogrel has been shown to reduce the rate of myocardial infarction…
Full Clopidogrel guide →How Each Drug Works
Celecoxib
Celecoxib has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of celecoxib capsules are believed to be due to inhibition of prostaglandin synthesis, primarily via inhibition of COX-2. Celecoxib is a potent inhibitor of prostaglandin synthesis in vitro. Celecoxib concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal m…
Clopidogrel
Clopidogrel is an inhibitor of platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y 12 class of ADP receptors on platelets.
Approved Uses (Indications)
Celecoxib
Celecoxib capsules are indicated Celecoxib capsules are a nonsteroidal anti-inflammatory drug indicated for:
- Osteoarthritis (OA)
- Rheumatoid Arthritis (RA)
- Juvenile Rheumatoid Arthritis (JRA) in patients 2 years and older
- Ankylosing Spondylitis (AS)
- Acute Pain (AP)
- Primary Dysmenorrhea (PD) 1.1 Osteoarthritis(OA) For the management of the signs and symptoms of OA [ see Clinical Studies ] 1.2 Rheumatoid Arthritis(RA) For the management of the signs and symptoms of RA [ see Clinical Studies ] 1.3…
Clopidogrel
Clopidogrel is a P2Y 12 platelet inhibitor indicated for:
- Acute coronary syndrome - For patients with non-ST-segment elevation ACS (unstable angina [UA]/non-ST-elevation myocardial infarction [NSTEMI]), clopidogrel has been shown to reduce the rate of myocardial infarction (MI) and stroke. - For patients with ST-elevation myocardial infarction (STEMI), clopidogrel has been shown to reduce the rate of MI and stroke.
- Recent MI, recent stroke, or established peripheral arterial disease. Clopidogrel has been shown to reduce the rate of MI and stroke. ( 1.2…
Side Effects
Celecoxib
Clopidogrel
Cost Comparison
Celecoxib
$150–$400/month
Since Celecoxib is available as a generic, comparing prices at different pharmacies and using discount cards like GoodRx can significantly reduce your out-of-pocket cost. Some manufacturers also offer patient assistance programs for those who qualify.
Clopidogrel
$10–$30/month
Clopidogrel is available as a low-cost generic. Using discount cards like GoodRx can further reduce the price, often bringing it down to under $10 per month.
Compare prices for Celecoxib and Clopidogrel
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.