Combining Celecoxib and Dabigatran Etexilate Mesylate is a major interaction and should generally be avoided without close medical supervision.
Combining celecoxib with dabigatran significantly increases your risk of bleeding, especially from the stomach or intestines. This combination should generally be avoided due to the serious bleeding potential.
Mechanism: Celecoxib, a COX-2 selective NSAID, inhibits prostaglandin synthesis, which can impair gastric mucosal defense and platelet function (to a lesser extent than non-selective NSAIDs). Dabigatran is a direct thrombin inhibitor, which prevents clot formation. Their combined effect leads to an additive increase in bleeding risk by affecting both primary hemostasis and the coagulation cascade.
Celecoxib vs. Dabigatran Etexilate Mesylate
Compare Celecoxib and Dabigatran Etexilate Mesylate: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Celecoxib
celecoxib
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxDrug B
Dabigatran Etexilate Mesylate
Pradaxa
Anticoagulants
RxQuick Comparison
| Category | Celecoxib | Dabigatran Etexilate Mesylate |
|---|---|---|
| Drug Class | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) | Anticoagulants |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $150–$400/month | $400–$600/month |
Celecoxib Overview
CELECOXIB (brand name: celecoxib) is a NSAIDs. 1 INDICATIONS AND USAGE Celecoxib capsules are indicated Celecoxib capsules are a nonsteroidal anti-inflammatory drug indicated for: • Osteoarthritis (OA) ( 1.1 ) • Rheumatoid Arthritis (RA) ( 1.2 ) • Juvenile Rheumatoid Arthritis (JRA) in patients 2 years and older ( 1.3 ) • Ankylosing Spondylitis…
Full Celecoxib guide →Dabigatran Etexilate Mesylate Overview
Dabigatran (Pradaxa) is a medication that helps prevent blood clots from forming in your body. It works by directly blocking a substance called thrombin, which is essential for blood clotting. This medicine is primarily used to reduce the risk of stroke in people with a type of irregular heartbeat called atrial fibrillation, and to treat or prevent deep vein clots (DVT) and lung clots (PE) in cert...
Full Dabigatran Etexilate Mesylate guide →How Each Drug Works
Celecoxib
Celecoxib has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of celecoxib capsules are believed to be due to inhibition of prostaglandin synthesis, primarily via inhibition of COX-2. Celecoxib is a potent inhibitor of prostaglandin synthesis in vitro. Celecoxib concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal m…
Dabigatran Etexilate Mesylate
Dabigatran and its acyl glucuronides are competitive, direct thrombin inhibitors. Because thrombin (serine protease) enables the conversion of fibrinogen into fibrin during the coagulation cascade, its inhibition prevents the development of a thrombus. Both free and clot-bound thrombin, and thrombin-induced platelet aggregation are inhibited by the active moieties.
Approved Uses (Indications)
Celecoxib
Celecoxib capsules are indicated Celecoxib capsules are a nonsteroidal anti-inflammatory drug indicated for:
- Osteoarthritis (OA)
- Rheumatoid Arthritis (RA)
- Juvenile Rheumatoid Arthritis (JRA) in patients 2 years and older
- Ankylosing Spondylitis (AS)
- Acute Pain (AP)
- Primary Dysmenorrhea (PD) 1.1 Osteoarthritis(OA) For the management of the signs and symptoms of OA [ see Clinical Studies ] 1.2 Rheumatoid Arthritis(RA) For the management of the signs and symptoms of RA [ see Clinical Studies ] 1.3…
Dabigatran Etexilate Mesylate
Capsules is a direct thrombin inhibitor indicated: To reduce the risk of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation For the treatment of deep venous thrombosis (DVT) and pulmonary embolism (PE) in adult patients who have been treated with a parenteral anticoagulant for 5-10 days To reduce the risk of recurrence of DVT and PE in adult patients who have been previously treated For the prophylaxis of DVT and PE in adult patients who have undergone hip replacement surgery For the treatment of …
Side Effects
Celecoxib
Dabigatran Etexilate Mesylate
Cost Comparison
Celecoxib
$150–$400/month
Since Celecoxib is available as a generic, comparing prices at different pharmacies and using discount cards like GoodRx can significantly reduce your out-of-pocket cost. Some manufacturers also offer patient assistance programs for those who qualify.
Dabigatran Etexilate Mesylate
$400–$600/month
As Pradaxa is a brand-name medication without a generic, manufacturer coupons or patient assistance programs are often the best ways to reduce out-of-pocket costs.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.