Combining Celecoxib and Edoxaban Tosylate is a major interaction and should generally be avoided without close medical supervision.
Combining celecoxib with edoxaban significantly increases your risk of serious bleeding, including internal bleeding. This combination should generally be avoided due to the heightened bleeding risk.
Mechanism: Celecoxib, an NSAID, inhibits prostaglandin synthesis, which can impair gastric mucosal defense and platelet aggregation, thereby increasing the risk of gastrointestinal bleeding. Edoxaban is a direct oral anticoagulant (DOAC) that inhibits Factor Xa, preventing clot formation. The concurrent use of these agents results in additive antiplatelet and anticoagulant effects, leading to a synergistic increase in bleeding risk.
Celecoxib vs. Edoxaban Tosylate
Compare Celecoxib and Edoxaban Tosylate: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Celecoxib
celecoxib
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxDrug B
Edoxaban Tosylate
Savaysa
Anticoagulants
RxQuick Comparison
| Category | Celecoxib | Edoxaban Tosylate |
|---|---|---|
| Drug Class | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) | Anticoagulants |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $150–$400/month | $400–$600/month |
Celecoxib Overview
CELECOXIB (brand name: celecoxib) is a NSAIDs. 1 INDICATIONS AND USAGE Celecoxib capsules are indicated Celecoxib capsules are a nonsteroidal anti-inflammatory drug indicated for: • Osteoarthritis (OA) ( 1.1 ) • Rheumatoid Arthritis (RA) ( 1.2 ) • Juvenile Rheumatoid Arthritis (JRA) in patients 2 years and older ( 1.3 ) • Ankylosing Spondylitis…
Full Celecoxib guide →Edoxaban Tosylate Overview
Savaysa (edoxaban tosylate) is a type of blood thinner that works by blocking a specific clotting factor in your blood. It is prescribed to reduce the risk of stroke and dangerous blood clots in people with a heart condition called nonvalvular atrial fibrillation. Savaysa is also used to treat existing deep vein clots in the legs (DVT) and blood clots in the lungs (PE) after initial treatment with...
Full Edoxaban Tosylate guide →How Each Drug Works
Celecoxib
Celecoxib has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of celecoxib capsules are believed to be due to inhibition of prostaglandin synthesis, primarily via inhibition of COX-2. Celecoxib is a potent inhibitor of prostaglandin synthesis in vitro. Celecoxib concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal m…
Edoxaban Tosylate
Edoxaban is a selective inhibitor of FXa. It does not require antithrombin III for antithrombotic activity. Edoxaban inhibits free FXa, and prothrombinase activity and inhibits thrombin-induced platelet aggregation. Inhibition of FXa in the coagulation cascade reduces thrombin generation and reduces thrombus formation.
Approved Uses (Indications)
Celecoxib
Celecoxib capsules are indicated Celecoxib capsules are a nonsteroidal anti-inflammatory drug indicated for:
- Osteoarthritis (OA)
- Rheumatoid Arthritis (RA)
- Juvenile Rheumatoid Arthritis (JRA) in patients 2 years and older
- Ankylosing Spondylitis (AS)
- Acute Pain (AP)
- Primary Dysmenorrhea (PD) 1.1 Osteoarthritis(OA) For the management of the signs and symptoms of OA [ see Clinical Studies ] 1.2 Rheumatoid Arthritis(RA) For the management of the signs and symptoms of RA [ see Clinical Studies ] 1.3…
Edoxaban Tosylate
1 INDICATIONS AND USAGE SAVAYSA is a factor Xa inhibitor indicated: To reduce the risk of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation (NVAF) Limitation of Use for NVAF SAVAYSA should not be used in patients with creatinine clearance (CrCL) > 95 mL/min because of increased risk of ischemic stroke compared to warfarin at the highest dose studied (60 mg) SAVAYSA is indicated for the treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) following 5 to 10 days of initial therapy with a parenteral anticoagulant
Reductio…
Side Effects
Celecoxib
Edoxaban Tosylate
Cost Comparison
Celecoxib
$150–$400/month
Since Celecoxib is available as a generic, comparing prices at different pharmacies and using discount cards like GoodRx can significantly reduce your out-of-pocket cost. Some manufacturers also offer patient assistance programs for those who qualify.
Edoxaban Tosylate
$400–$600/month
As SAVAYSA is a brand-name medication, manufacturer coupons or patient assistance programs are often the best ways to reduce out-of-pocket costs. Discount cards like GoodRx may also offer some savings, but manufacturer programs are usually more substantial.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.