Combining Celecoxib and Enoxaparin Sodium is a major interaction and should generally be avoided without close medical supervision.
Combining celecoxib (an NSAID) with enoxaparin (a blood thinner) significantly increases your risk of serious bleeding, including internal bleeding. This combination should generally be avoided.
Mechanism: Celecoxib, like other NSAIDs, inhibits prostaglandin synthesis, which can impair platelet function and disrupt the integrity of the gastrointestinal mucosa. Enoxaparin directly inhibits clotting factors, primarily Factor Xa, leading to reduced blood clot formation. The concurrent use of these agents results in an additive antihemostatic effect.
Celecoxib vs. Enoxaparin Sodium
Compare Celecoxib and Enoxaparin Sodium: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Celecoxib
celecoxib
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxDrug B
Enoxaparin Sodium
Enoxaparin Sodium
Anticoagulants
RxQuick Comparison
| Category | Celecoxib | Enoxaparin Sodium |
|---|---|---|
| Drug Class | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) | Anticoagulants |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $150–$400/month | $150-$600/month |
Celecoxib Overview
CELECOXIB (brand name: celecoxib) is a NSAIDs. 1 INDICATIONS AND USAGE Celecoxib capsules are indicated Celecoxib capsules are a nonsteroidal anti-inflammatory drug indicated for: • Osteoarthritis (OA) ( 1.1 ) • Rheumatoid Arthritis (RA) ( 1.2 ) • Juvenile Rheumatoid Arthritis (JRA) in patients 2 years and older ( 1.3 ) • Ankylosing Spondylitis…
Full Celecoxib guide →Enoxaparin Sodium Overview
Enoxaparin Sodium is a type of medicine known as a blood thinner, specifically a low molecular weight heparin. It works by helping to prevent and treat dangerous blood clots, such as those that can form in the legs (deep vein thrombosis or DVT) or travel to the lungs (pulmonary embolism). This medication is also used to help manage certain heart conditions like unstable angina or heart attacks.
Full Enoxaparin Sodium guide →How Each Drug Works
Celecoxib
Celecoxib has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of celecoxib capsules are believed to be due to inhibition of prostaglandin synthesis, primarily via inhibition of COX-2. Celecoxib is a potent inhibitor of prostaglandin synthesis in vitro. Celecoxib concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal m…
Enoxaparin Sodium
Enoxaparin is a low molecular weight heparin which has antithrombotic properties.
Approved Uses (Indications)
Celecoxib
Celecoxib capsules are indicated Celecoxib capsules are a nonsteroidal anti-inflammatory drug indicated for:
- Osteoarthritis (OA)
- Rheumatoid Arthritis (RA)
- Juvenile Rheumatoid Arthritis (JRA) in patients 2 years and older
- Ankylosing Spondylitis (AS)
- Acute Pain (AP)
- Primary Dysmenorrhea (PD) 1.1 Osteoarthritis(OA) For the management of the signs and symptoms of OA [ see Clinical Studies ] 1.2 Rheumatoid Arthritis(RA) For the management of the signs and symptoms of RA [ see Clinical Studies ] 1.3…
Enoxaparin Sodium
Enoxaparin Sodium Injection is a low molecular weight heparin (LMWH) indicated for: Prophylaxis of deep vein thrombosis (DVT) in abdominal surgery, hip replacement surgery, knee replacement surgery, or medical patients with severely restricted mobility during acute illness Inpatient treatment of acute DVT with or without pulmonary embolism Outpatient treatment of acute DVT without pulmonary embolism Prophylaxis of ischemic complications of unstable angina and non-Q-wave myocardial infarction (MI) Treatment of acute ST-segment elevation my…
Side Effects
Celecoxib
Enoxaparin Sodium
Cost Comparison
Celecoxib
$150–$400/month
Since Celecoxib is available as a generic, comparing prices at different pharmacies and using discount cards like GoodRx can significantly reduce your out-of-pocket cost. Some manufacturers also offer patient assistance programs for those who qualify.
Enoxaparin Sodium
$150-$600/month
As a generic, enoxaparin sodium is much more affordable than its brand-name counterpart. Using discount cards like GoodRx can further reduce the cost significantly.
Compare prices for Celecoxib and Enoxaparin Sodium
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.