Celecoxib vs. Naproxen
Compare Celecoxib and Naproxen: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Celecoxib
celecoxib
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxDrug B
Naproxen
Naproxen
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Celecoxib | Naproxen |
|---|---|---|
| Drug Class | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $150–$400/month | $4–$25/month |
Celecoxib Overview
CELECOXIB (brand name: celecoxib) is a NSAIDs. 1 INDICATIONS AND USAGE Celecoxib capsules are indicated Celecoxib capsules are a nonsteroidal anti-inflammatory drug indicated for: • Osteoarthritis (OA) ( 1.1 ) • Rheumatoid Arthritis (RA) ( 1.2 ) • Juvenile Rheumatoid Arthritis (JRA) in patients 2 years and older ( 1.3 ) • Ankylosing Spondylitis…
Full Celecoxib guide →Naproxen Overview
NAPROXEN (brand name: Naproxen) is a NSAIDs. 1 INDICATIONS & USAGE Naproxen delayed-release tablets are indicated for: the relief of the signs and symptoms of: rheumatoid arthritis osteoarthritis ankylosing spondylitis Polyarticular Juvenile Idiopathic Arthritis Naproxen delayed-release tablets are non-steroidal anti-inflammatory drugs…
Full Naproxen guide →How Each Drug Works
Celecoxib
Celecoxib has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of celecoxib capsules are believed to be due to inhibition of prostaglandin synthesis, primarily via inhibition of COX-2. Celecoxib is a potent inhibitor of prostaglandin synthesis in vitro. Celecoxib concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal m…
Naproxen
Naproxen has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of naproxen, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Naproxen is a potent inhibitor of prostaglandin synthesis in vitro. Naproxen concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in ani…
Approved Uses (Indications)
Celecoxib
Celecoxib capsules are indicated Celecoxib capsules are a nonsteroidal anti-inflammatory drug indicated for:
- Osteoarthritis (OA)
- Rheumatoid Arthritis (RA)
- Juvenile Rheumatoid Arthritis (JRA) in patients 2 years and older
- Ankylosing Spondylitis (AS)
- Acute Pain (AP)
- Primary Dysmenorrhea (PD) 1.1 Osteoarthritis(OA) For the management of the signs and symptoms of OA [ see Clinical Studies ] 1.2 Rheumatoid Arthritis(RA) For the management of the signs and symptoms of RA [ see Clinical Studies ] 1.3…
Naproxen
Naproxen delayed-release tablets are indicated for: the relief of the signs and symptoms of: rheumatoid arthritis osteoarthritis ankylosing spondylitis Polyarticular Juvenile Idiopathic Arthritis Naproxen delayed-release tablets are non-steroidal anti-inflammatory drugs indicated for: the relief of the signs and symptoms of: rheumatoid arthritis osteoarthritis ankylosing spondylitis polyarticular juvenile idiopathic arthritis
Side Effects
Celecoxib
Naproxen
Cost Comparison
Celecoxib
$150–$400/month
Since Celecoxib is available as a generic, comparing prices at different pharmacies and using discount cards like GoodRx can significantly reduce your out-of-pocket cost. Some manufacturers also offer patient assistance programs for those who qualify.
Naproxen
$4–$25/month
Naproxen is widely available as an affordable generic. Using discount cards like GoodRx can further reduce the cost, often bringing it to under $10 per month.
Drug Interaction: Moderate
Concomitant use of celecoxib and naproxen, both non-steroidal anti-inflammatory drugs (NSAIDs), significantly increases the risk of gastrointestinal adverse events, including ulcers, bleeding, and perforation, as well as renal toxicity and cardiovascular events. There is no evidence of increased efficacy with this combination compared to monotherapy with either drug.
Mechanism: Both celecoxib (a selective COX-2 inhibitor) and naproxen (a non-selective COX inhibitor) exert their therapeutic and adverse effects by inhibiting prostaglandin synthesis. Concurrent administration leads to an additive pharmacological effect, increasing the suppression of protective prostaglandins in the gastrointestinal tract and kidneys, and potentially increasing prothrombotic effects.
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