Combining Celecoxib and Warfarin Sodium is a major interaction and should generally be avoided without close medical supervision.
Concomitant use of celecoxib with warfarin significantly increases the risk of serious bleeding events, including gastrointestinal hemorrhage. Patients may experience bruising, epistaxis, hematuria, or melena, potentially leading to hospitalization or death.
Mechanism: Celecoxib, a COX-2 inhibitor, can inhibit platelet aggregation to some extent and cause gastrointestinal irritation, increasing the risk of bleeding. It also displaces warfarin from plasma protein binding sites and inhibits warfarin metabolism (CYP2C9), leading to increased free warfarin concentrations and enhanced anticoagulant effect.
Celecoxib vs. Warfarin Sodium
Compare Celecoxib and Warfarin Sodium: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Celecoxib
celecoxib
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxDrug B
Warfarin Sodium
Warfarin Sodium
Anticoagulants
RxQuick Comparison
| Category | Celecoxib | Warfarin Sodium |
|---|---|---|
| Drug Class | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) | Anticoagulants |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $150–$400/month | $10–$50/month |
Celecoxib Overview
CELECOXIB (brand name: celecoxib) is a NSAIDs. 1 INDICATIONS AND USAGE Celecoxib capsules are indicated Celecoxib capsules are a nonsteroidal anti-inflammatory drug indicated for: • Osteoarthritis (OA) ( 1.1 ) • Rheumatoid Arthritis (RA) ( 1.2 ) • Juvenile Rheumatoid Arthritis (JRA) in patients 2 years and older ( 1.3 ) • Ankylosing Spondylitis…
Full Celecoxib guide →Warfarin Sodium Overview
Warfarin Sodium is a "blood thinner" (anticoagulant) medication that helps prevent and treat harmful blood clots in the body. It works by reducing the body's ability to form clots, which can help prevent serious conditions like strokes, heart attacks, and clots in the legs or lungs, especially in people with certain heart conditions or after a heart attack.
Full Warfarin Sodium guide →How Each Drug Works
Celecoxib
Celecoxib has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of celecoxib capsules are believed to be due to inhibition of prostaglandin synthesis, primarily via inhibition of COX-2. Celecoxib is a potent inhibitor of prostaglandin synthesis in vitro. Celecoxib concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal m…
Warfarin Sodium
Warfarin acts by inhibiting the synthesis of vitamin K-dependent clotting factors, which include Factors II, VII, IX, and X, and the anticoagulant proteins C and S. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K-dependent clotting factors. Vitamin K promotes the biosynthesis of γ-carboxyglutamic acid residues in the proteins that are essential for biological activity. Warfarin is thought to interfere with clotting factor synthesis by…
Approved Uses (Indications)
Celecoxib
Celecoxib capsules are indicated Celecoxib capsules are a nonsteroidal anti-inflammatory drug indicated for:
- Osteoarthritis (OA)
- Rheumatoid Arthritis (RA)
- Juvenile Rheumatoid Arthritis (JRA) in patients 2 years and older
- Ankylosing Spondylitis (AS)
- Acute Pain (AP)
- Primary Dysmenorrhea (PD) 1.1 Osteoarthritis(OA) For the management of the signs and symptoms of OA [ see Clinical Studies ] 1.2 Rheumatoid Arthritis(RA) For the management of the signs and symptoms of RA [ see Clinical Studies ] 1.3…
Warfarin Sodium
Warfarin sodium tablets are indicated for: Prophylaxis and treatment of venous thrombosis and its extension, pulmonary embolism (PE). Prophylaxis and treatment of thromboembolic complications associated with atrial fibrillation (AF) and/or cardiac valve replacement. Reduction in the risk of death, recurrent myocardial infarction (MI), and thromboembolic events such as stroke or systemic embolization after myocardial infarction. Limitations of Use Warfarin sodium tablets have no direct effect on an established thrombus, nor does it reverse ischemic tissue damage. Once a …
Side Effects
Celecoxib
Warfarin Sodium
Cost Comparison
Celecoxib
$150–$400/month
Since Celecoxib is available as a generic, comparing prices at different pharmacies and using discount cards like GoodRx can significantly reduce your out-of-pocket cost. Some manufacturers also offer patient assistance programs for those who qualify.
Warfarin Sodium
$10–$50/month
Warfarin Sodium is available as an affordable generic. Using discount cards like GoodRx can further reduce the cost, often bringing it down to under $10 per month at many pharmacies.
Compare prices for Celecoxib and Warfarin Sodium
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Medical Disclaimer
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