Combining Chlorzoxazone and Hydromorphone Hydrochloride is a major interaction and should generally be avoided without close medical supervision.
Patients may experience profound sedation, dizziness, impaired psychomotor function, and increased risk of falls. The most serious clinical effect is respiratory depression, which can be life-threatening. Other effects include hypotension and coma.
Mechanism: Hydromorphone, an opioid analgesic, acts on mu-opioid receptors in the central nervous system (CNS) to produce analgesia, sedation, and respiratory depression. Chlorzoxazone, a centrally acting muscle relaxant, also exerts its effects within the CNS, primarily by inhibiting polysynaptic reflex arcs. The co-administration of these agents results in an additive depressant effect on the CNS.
Chlorzoxazone vs. Hydromorphone Hydrochloride
Compare Chlorzoxazone and Hydromorphone Hydrochloride: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Chlorzoxazone
Chlorzoxazone
Skeletal Muscle Relaxants
RxDrug B
Hydromorphone Hydrochloride
Hydromorphone Hydrochloride
Opioid Analgesics
RxQuick Comparison
| Category | Chlorzoxazone | Hydromorphone Hydrochloride |
|---|---|---|
| Drug Class | Skeletal Muscle Relaxants | Opioid Analgesics |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $50–$150/month | $200–$500/month |
Chlorzoxazone Overview
Chlorzoxazone is a medication used to help relieve discomfort from sudden, painful muscle and bone conditions. It works by affecting the central nervous system, which helps reduce pain and muscle spasms, often alongside rest and physical therapy.
Full Chlorzoxazone guide →Hydromorphone Hydrochloride Overview
HYDROMORPHONE HYDROCHLORIDE (brand name: Hydromorphone Hydrochloride) is a Opioid Analgesics. INDICATIONS AND USAGE Hydromorphone Hydrochloride Injection is indicated for the relief of moderate to severe pain such as that due to: surgery, cancer, trauma (soft tissue and bone), biliary colic, myocardial infarction, burns, renal colic.
Full Hydromorphone Hydrochloride guide →Approved Uses (Indications)
Chlorzoxazone
INDICATIONS AND USAGE Chlorzoxazone is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Chlorzoxazone does not directly relax tense skeletal muscles in man.
Hydromorphone Hydrochloride
INDICATIONS AND USAGE Hydromorphone Hydrochloride Injection is indicated for the relief of moderate to severe pain such as that due to: surgery, cancer, trauma (soft tissue and bone), biliary colic, myocardial infarction, burns, renal colic.
Side Effects
Chlorzoxazone
Hydromorphone Hydrochloride
Cost Comparison
Chlorzoxazone
$50–$150/month
As a brand-only medication, Chlorzoxazone can be expensive. Patients should check for manufacturer coupons or patient assistance programs, and compare prices at different pharmacies using discount cards.
Hydromorphone Hydrochloride
$200–$500/month
As a brand-only medication, costs without insurance can be high. Discuss patient assistance programs with your doctor or pharmacist for potential savings.
Compare prices for Chlorzoxazone and Hydromorphone Hydrochloride
Check real-time pharmacy prices before you fill — free, no account needed.
Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.