Combining Chlorzoxazone and Methadone is a major interaction and should generally be avoided without close medical supervision.
Patients may experience profound sedation, dizziness, and confusion. There is an increased risk of respiratory depression, which can be life-threatening, and psychomotor impairment, leading to an elevated risk of falls and accidents. Other effects include hypotension and decreased level of consciousness.
Mechanism: Both methadone, an opioid analgesic, and chlorzoxazone, a centrally acting skeletal muscle relaxant, exert depressant effects on the central nervous system (CNS). The co-administration of these agents leads to an additive pharmacological effect, increasing the overall CNS depression. This synergistic action can significantly impair neuronal activity in various brain regions.
Chlorzoxazone vs. Methadone
Compare Chlorzoxazone and Methadone: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Chlorzoxazone
Chlorzoxazone
Skeletal Muscle Relaxants
RxDrug B
Methadone
Methadone Hydrochloride
Opioid Analgesics
RxQuick Comparison
| Category | Chlorzoxazone | Methadone |
|---|---|---|
| Drug Class | Skeletal Muscle Relaxants | Opioid Analgesics |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $50–$150/month | $15–$60/month |
Chlorzoxazone Overview
Chlorzoxazone is a medication used to help relieve discomfort from sudden, painful muscle and bone conditions. It works by affecting the central nervous system, which helps reduce pain and muscle spasms, often alongside rest and physical therapy.
Full Chlorzoxazone guide →Methadone Overview
METHADONE (brand name: Methadone Hydrochloride) is a Opioid Analgesics. 1 INDICATIONS AND USAGE Methadone hydrochloride tablets is indicated for the: Management of severe and persistent pain that requires an opioid analgesic and that cannot be adequately treated with alternative options, including immediate-release opioids. Limitations of Use Because of the risks of…
Full Methadone guide →How Each Drug Works
Methadone
Methadone hydrochloride is a mu-agonist; a synthetic opioid with multiple actions qualitatively similar to those of morphine, the most prominent of which involves the central nervous system and organs composed of smooth muscle. The principal therapeutic uses for methadone are for analgesia and for detoxification or maintenance in opioid addiction. The methadone withdrawal syndrome, although qualitatively similar to that of morphine, differs in that the onset is slower, t…
Approved Uses (Indications)
Chlorzoxazone
INDICATIONS AND USAGE Chlorzoxazone is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Chlorzoxazone does not directly relax tense skeletal muscles in man.
Methadone
Methadone hydrochloride tablets is indicated for the: Management of severe and persistent pain that requires an opioid analgesic and that cannot be adequately treated with alternative options, including immediate-release opioids. Limitations of Use Because of the risks of addiction, abuse, misuse, overdose, and death, which can occur at any dosage or duration and persist over the course of therapy [see WARNINGS AND PRECAUTIONS ], reserve opioid analgesics, including methadone hydrochloride tablets, for use in patients for whom alternative analgesic treatment opti…
Side Effects
Chlorzoxazone
Methadone
Cost Comparison
Chlorzoxazone
$50–$150/month
As a brand-only medication, Chlorzoxazone can be expensive. Patients should check for manufacturer coupons or patient assistance programs, and compare prices at different pharmacies using discount cards.
Methadone
$15–$60/month
Generic methadone is very affordable, especially with discount cards like GoodRx. Many pharmacies offer low-cost programs for this medication.
Compare prices for Chlorzoxazone and Methadone
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.