Combining Cilostazol and Etodolac is a major interaction and should generally be avoided without close medical supervision.
Combining Etodolac and Cilostazol significantly increases your risk of bleeding, especially in the stomach or intestines. This combination should generally be avoided.
Mechanism: Etodolac, a non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis and impairing platelet aggregation. Cilostazol is an antiplatelet agent that inhibits phosphodiesterase-3, leading to increased cyclic AMP and further inhibition of platelet aggregation. The concurrent use of these drugs results in additive antiplatelet effects, significantly increasing the risk of bleeding.
Cilostazol vs. Etodolac
Compare Cilostazol and Etodolac: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Cilostazol
Cilostazol
Antiplatelet Agents
RxDrug B
Etodolac
Etodolac
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Cilostazol | Etodolac |
|---|---|---|
| Drug Class | Antiplatelet Agents | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $50–$150/month | $15-$60/month |
Cilostazol Overview
Cilostazol is a medication that belongs to a class of drugs called phosphodiesterase III inhibitors. It is primarily used to help people with a condition called intermittent claudication, which causes leg pain during exercise due to poor blood flow. By improving blood flow and preventing blood clots, cilostazol helps reduce these symptoms and allows patients to walk further without pain.
Full Cilostazol guide →Etodolac Overview
ETODOLAC (brand name: Etodolac) is a NSAIDs. INDICATIONS AND USAGE Carefully consider the potential benefits and risks of etodolac extended-release tablets and other treatment options before deciding to use etodolac extended-release tablets. Use the lowest effective dose for the shortest duration consistent with individual patient treatment…
Full Etodolac guide →How Each Drug Works
Cilostazol
Cilostazol and several of its metabolites inhibit phosphodiesterase III activity and suppress cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation, respectively. Cilostazol reversibly inhibits platelet aggregation induced by a variety of stimuli, including thrombin, ADP, collagen, arachidonic acid, epinephrine, and shear stress. Cardiovascular effects: Cilostazol affects both vas…
Approved Uses (Indications)
Cilostazol
Cilostazol tablets are indicated for the reduction of symptoms of intermittent claudication, as demonstrated by an increased walking distance. Cilostazol tablets are a phosphodiesterase III inhibitor (PDE III inhibitor) indicated for the reduction of symptoms of intermittent claudication, as demonstrated by an increased walking distance
Etodolac
INDICATIONS AND USAGE Carefully consider the potential benefits and risks of etodolac extended-release tablets and other treatment options before deciding to use etodolac extended-release tablets. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS ). Etodolac extended-release tablets are indicated: * For relief of signs and symptoms of juvenile arthritis * For relief of the signs and symptoms of rheumatoid arthritis * For relief of the signs and symptoms of osteoarthritis
Side Effects
Cilostazol
Etodolac
Cost Comparison
Cilostazol
$50–$150/month
Since Cilostazol is available as a generic, comparing prices at different pharmacies and using discount cards like GoodRx can significantly reduce your monthly cost. Manufacturer coupons may also be available for the brand-name version if preferred.
Etodolac
$15-$60/month
Since Etodolac is available as a generic, using discount cards like GoodRx can significantly reduce the cash price. Always compare prices at different pharmacies.
Compare prices for Cilostazol and Etodolac
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.