Combining Cilostazol and Indomethacin is a major interaction and should generally be avoided without close medical supervision.
Combining indomethacin with cilostazol significantly increases your risk of bleeding, especially in the stomach and intestines. This combination should generally be avoided.
Mechanism: Indomethacin, an NSAID, inhibits cyclooxygenase (COX) enzymes, leading to reduced prostaglandin synthesis and impaired platelet aggregation. Cilostazol is a phosphodiesterase-3 inhibitor that also reduces platelet aggregation and causes vasodilation. The concurrent use of these two drugs results in additive antiplatelet effects, significantly increasing the risk of bleeding.
Cilostazol vs. Indomethacin
Compare Cilostazol and Indomethacin: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Cilostazol
Cilostazol
Antiplatelet Agents
RxDrug B
Indomethacin
Indomethacin
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Cilostazol | Indomethacin |
|---|---|---|
| Drug Class | Antiplatelet Agents | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $50–$150/month | $30–$80/month |
Cilostazol Overview
Cilostazol is a medication that belongs to a class of drugs called phosphodiesterase III inhibitors. It is primarily used to help people with a condition called intermittent claudication, which causes leg pain during exercise due to poor blood flow. By improving blood flow and preventing blood clots, cilostazol helps reduce these symptoms and allows patients to walk further without pain.
Full Cilostazol guide →Indomethacin Overview
INDOMETHACIN (brand name: Indomethacin) is a NSAIDs. INDICATIONS AND USAGE Carefully consider the potential benefits and risks of indomethacin capsules and other treatment options before deciding to use indomethacin. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS ).…
Full Indomethacin guide →How Each Drug Works
Cilostazol
Cilostazol and several of its metabolites inhibit phosphodiesterase III activity and suppress cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation, respectively. Cilostazol reversibly inhibits platelet aggregation induced by a variety of stimuli, including thrombin, ADP, collagen, arachidonic acid, epinephrine, and shear stress. Cardiovascular effects: Cilostazol affects both vas…
Approved Uses (Indications)
Cilostazol
Cilostazol tablets are indicated for the reduction of symptoms of intermittent claudication, as demonstrated by an increased walking distance. Cilostazol tablets are a phosphodiesterase III inhibitor (PDE III inhibitor) indicated for the reduction of symptoms of intermittent claudication, as demonstrated by an increased walking distance
Indomethacin
INDICATIONS AND USAGE Carefully consider the potential benefits and risks of indomethacin capsules and other treatment options before deciding to use indomethacin. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS ). Indomethacin Capsule, USP has been found effective in active stages of the following: Moderate to severe rheumatoid arthritis including acute flares of chronic disease. Moderate to severe ankylosing spondylitis. Moderate to severe osteoarthritis. Acute painful shoulder (bursitis and/or tendinitis). Acute gouty …
Side Effects
Cilostazol
Indomethacin
Cost Comparison
Cilostazol
$50–$150/month
Since Cilostazol is available as a generic, comparing prices at different pharmacies and using discount cards like GoodRx can significantly reduce your monthly cost. Manufacturer coupons may also be available for the brand-name version if preferred.
Indomethacin
$30–$80/month
While Indomethacin is available generically, its brand name is also Indomethacin. Using discount cards like GoodRx can often help reduce the cost significantly.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.