Combining Cilostazol and Ketorolac Tromethamine is a major interaction and should generally be avoided without close medical supervision.
Combining ketorolac with cilostazol significantly increases your risk of bleeding, especially in the stomach or intestines. This combination should generally be avoided.
Mechanism: Ketorolac, a non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase enzymes, reducing prostaglandin synthesis and impairing platelet aggregation. Cilostazol is a phosphodiesterase-3 inhibitor that directly inhibits platelet aggregation and causes vasodilation. The concurrent use of these agents leads to an additive antiplatelet effect, significantly increasing the risk of hemorrhage.
Cilostazol vs. Ketorolac Tromethamine
Compare Cilostazol and Ketorolac Tromethamine: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Cilostazol
Cilostazol
Antiplatelet Agents
RxDrug B
Ketorolac Tromethamine
Ketorolac Tromethamine
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Cilostazol | Ketorolac Tromethamine |
|---|---|---|
| Drug Class | Antiplatelet Agents | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $50–$150/month | $10–$50/month |
Cilostazol Overview
Cilostazol is a medication that belongs to a class of drugs called phosphodiesterase III inhibitors. It is primarily used to help people with a condition called intermittent claudication, which causes leg pain during exercise due to poor blood flow. By improving blood flow and preventing blood clots, cilostazol helps reduce these symptoms and allows patients to walk further without pain.
Full Cilostazol guide →Ketorolac Tromethamine Overview
KETOROLAC TROMETHAMINE (brand name: Ketorolac Tromethamine) is a NSAIDs. INDICATIONS AND USAGE Carefully consider the potential benefits and risks of Ketorolac Tromethamine Tablets USP and other treatment options before deciding to use Ketorolac Tromethamine Tablets USP. Use the lowest effective dose for the shortest duration consistent with individual patient treatment…
Full Ketorolac Tromethamine guide →How Each Drug Works
Cilostazol
Cilostazol and several of its metabolites inhibit phosphodiesterase III activity and suppress cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation, respectively. Cilostazol reversibly inhibits platelet aggregation induced by a variety of stimuli, including thrombin, ADP, collagen, arachidonic acid, epinephrine, and shear stress. Cardiovascular effects: Cilostazol affects both vas…
Approved Uses (Indications)
Cilostazol
Cilostazol tablets are indicated for the reduction of symptoms of intermittent claudication, as demonstrated by an increased walking distance. Cilostazol tablets are a phosphodiesterase III inhibitor (PDE III inhibitor) indicated for the reduction of symptoms of intermittent claudication, as demonstrated by an increased walking distance
Ketorolac Tromethamine
INDICATIONS AND USAGE Carefully consider the potential benefits and risks of Ketorolac Tromethamine Tablets USP and other treatment options before deciding to use Ketorolac Tromethamine Tablets USP. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals. Acute Pain in Adult Patients Ketorolac Tromethamine Tablets USP are indicated for the short-term (≤ 5 days) management of moderately severe acute pain that requires analgesia at the opioid level, usually in a postoperative setting. Therapy should always be initiated with IV or IM dosing of ke…
Side Effects
Cilostazol
Ketorolac Tromethamine
Cost Comparison
Cilostazol
$50–$150/month
Since Cilostazol is available as a generic, comparing prices at different pharmacies and using discount cards like GoodRx can significantly reduce your monthly cost. Manufacturer coupons may also be available for the brand-name version if preferred.
Ketorolac Tromethamine
$10–$50/month
As a widely available generic, Ketorolac Tromethamine is typically inexpensive. Using discount cards like GoodRx can often reduce the cost further to just a few dollars per month.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.