Combining Cilostazol and Meloxicam is a major interaction and should generally be avoided without close medical supervision.
Combining meloxicam with cilostazol significantly increases your risk of serious bleeding, including stomach or intestinal bleeding. This combination should generally be avoided.
Mechanism: Meloxicam, a non-steroidal anti-inflammatory drug (NSAID), inhibits prostaglandin synthesis, which can impair platelet function and damage the gastrointestinal mucosa. Cilostazol is a phosphodiesterase-3 inhibitor that directly inhibits platelet aggregation and causes vasodilation. The co-administration of these agents results in additive antiplatelet effects and increased gastrointestinal mucosal damage, leading to a synergistic increase in bleeding risk.
Cilostazol vs. Meloxicam
Compare Cilostazol and Meloxicam: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Cilostazol
Cilostazol
Antiplatelet Agents
RxDrug B
Meloxicam
meloxicam
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Cilostazol | Meloxicam |
|---|---|---|
| Drug Class | Antiplatelet Agents | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $50–$150/month | $4–$20/month |
Cilostazol Overview
Cilostazol is a medication that belongs to a class of drugs called phosphodiesterase III inhibitors. It is primarily used to help people with a condition called intermittent claudication, which causes leg pain during exercise due to poor blood flow. By improving blood flow and preventing blood clots, cilostazol helps reduce these symptoms and allows patients to walk further without pain.
Full Cilostazol guide →Meloxicam Overview
MELOXICAM (brand name: meloxicam) is a NSAIDs. 1 INDICATIONS AND USAGE Meloxicam Tablets are non-steroidal anti-inflammatory drug indicated for: Osteoarthritis (OA) ( 1.1 ) Rheumatoid Arthritis (RA) ( 1.2 ) Juvenile Rheumatoid Arthritis (JRA) in patients who weigh ≥ 60 kg ( 1.3 ) 1.1 Osteoarthritis (OA) Meloxicam tablets are indicated for…
Full Meloxicam guide →How Each Drug Works
Cilostazol
Cilostazol and several of its metabolites inhibit phosphodiesterase III activity and suppress cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation, respectively. Cilostazol reversibly inhibits platelet aggregation induced by a variety of stimuli, including thrombin, ADP, collagen, arachidonic acid, epinephrine, and shear stress. Cardiovascular effects: Cilostazol affects both vas…
Meloxicam
Meloxicam has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of meloxicam, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Meloxicam is a potent inhibitor of prostaglandin synthesis in vitro . Meloxicam concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain i…
Approved Uses (Indications)
Cilostazol
Cilostazol tablets are indicated for the reduction of symptoms of intermittent claudication, as demonstrated by an increased walking distance. Cilostazol tablets are a phosphodiesterase III inhibitor (PDE III inhibitor) indicated for the reduction of symptoms of intermittent claudication, as demonstrated by an increased walking distance
Meloxicam
Meloxicam Tablets are non-steroidal anti-inflammatory drug indicated for: Osteoarthritis (OA) Rheumatoid Arthritis (RA) Juvenile Rheumatoid Arthritis (JRA) in patients who weigh ≥ 60 kg 1.1 Osteoarthritis (OA) Meloxicam tablets are indicated for relief of the signs and symptoms of osteoarthritis [see Clinical Studies ]. 1.2 Rheumatoid Arthritis (RA) Meloxicam tablets are indicated for relief of the signs and symptoms of rheumatoid arthritis [see Clinical Studies ].
Juvenile Rheumatoid Arthritis (JRA) Pauciarticular and Polya…
Side Effects
Cilostazol
Meloxicam
Cost Comparison
Cilostazol
$50–$150/month
Since Cilostazol is available as a generic, comparing prices at different pharmacies and using discount cards like GoodRx can significantly reduce your monthly cost. Manufacturer coupons may also be available for the brand-name version if preferred.
Meloxicam
$4–$20/month
Meloxicam is available as an inexpensive generic. Patients can significantly reduce costs using discount cards or by checking prices at different pharmacies.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.