Combining Cilostazol and Piroxicam is a major interaction and should generally be avoided without close medical supervision.
Combining piroxicam with cilostazol significantly increases your risk of bleeding, especially in the stomach or intestines. This combination should generally be avoided.
Mechanism: Piroxicam, a non-steroidal anti-inflammatory drug (NSAID), inhibits prostaglandin synthesis, which can impair gastric mucosal protection and inhibit platelet aggregation. Cilostazol is a phosphodiesterase-3 inhibitor that directly inhibits platelet aggregation and causes vasodilation. The concurrent use of these agents results in additive antiplatelet effects and increased gastrointestinal toxicity, leading to a substantially elevated bleeding risk.
Cilostazol vs. Piroxicam
Compare Cilostazol and Piroxicam: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Cilostazol
Cilostazol
Antiplatelet Agents
RxDrug B
Piroxicam
Piroxicam
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Cilostazol | Piroxicam |
|---|---|---|
| Drug Class | Antiplatelet Agents | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $50–$150/month | $10–$30/month |
Cilostazol Overview
Cilostazol is a medication that belongs to a class of drugs called phosphodiesterase III inhibitors. It is primarily used to help people with a condition called intermittent claudication, which causes leg pain during exercise due to poor blood flow. By improving blood flow and preventing blood clots, cilostazol helps reduce these symptoms and allows patients to walk further without pain.
Full Cilostazol guide →Piroxicam Overview
PIROXICAM (brand name: Piroxicam) is a NSAIDs. 1 INDICATIONS AND USAGE Piroxicam capsules are indicated: • For relief of the signs and symptoms of osteoarthritis. • For relief of the signs and symptoms of rheumatoid arthritis. Piroxicam capsules are a nonsteroidal anti-inflammatory drug indicated for •Relief of the signs and symptoms of…
Full Piroxicam guide →How Each Drug Works
Cilostazol
Cilostazol and several of its metabolites inhibit phosphodiesterase III activity and suppress cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation, respectively. Cilostazol reversibly inhibits platelet aggregation induced by a variety of stimuli, including thrombin, ADP, collagen, arachidonic acid, epinephrine, and shear stress. Cardiovascular effects: Cilostazol affects both vas…
Piroxicam
Piroxicam has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of piroxicam capsules, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Piroxicam is a potent inhibitor of prostaglandin (PG) synthesis in vitro. Piroxicam concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in in…
Approved Uses (Indications)
Cilostazol
Cilostazol tablets are indicated for the reduction of symptoms of intermittent claudication, as demonstrated by an increased walking distance. Cilostazol tablets are a phosphodiesterase III inhibitor (PDE III inhibitor) indicated for the reduction of symptoms of intermittent claudication, as demonstrated by an increased walking distance
Piroxicam
Piroxicam capsules are indicated:
- For relief of the signs and symptoms of osteoarthritis.
- For relief of the signs and symptoms of rheumatoid arthritis. Piroxicam capsules are a nonsteroidal anti-inflammatory drug indicated for
- Relief of the signs and symptoms of osteoarthritis (OA)
- Relief of the signs and symptoms of rheumatoid arthritis (RA)
Side Effects
Cilostazol
Piroxicam
Cost Comparison
Cilostazol
$50–$150/month
Since Cilostazol is available as a generic, comparing prices at different pharmacies and using discount cards like GoodRx can significantly reduce your monthly cost. Manufacturer coupons may also be available for the brand-name version if preferred.
Piroxicam
$10–$30/month
Piroxicam is available as an affordable generic. Patients can often find significant savings by using discount cards or coupons from services like GoodRx.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.