Citalopram vs. Nebivolol
Compare Citalopram and Nebivolol: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Citalopram
Citalopram
SSRIs (Selective Serotonin Reuptake Inhibitors)
RxDrug B
Nebivolol
Nebivolol
Beta-Blockers
RxQuick Comparison
| Category | Citalopram | Nebivolol |
|---|---|---|
| Drug Class | SSRIs (Selective Serotonin Reuptake Inhibitors) | Beta-Blockers |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $4–$25/month | $200–$500/month |
Citalopram Overview
Citalopram is a medication called a selective serotonin reuptake inhibitor (SSRI) used to treat major depressive disorder in adults. It works by helping to restore the balance of a natural substance called serotonin in the brain, which can improve mood and feelings of well-being.
Full Citalopram guide →Nebivolol Overview
Nebivolol is a beta-blocker medication used to treat high blood pressure (hypertension). By helping to relax blood vessels and slow the heart rate, it lowers blood pressure, which in turn reduces the risk of serious heart problems like strokes and heart attacks.
Full Nebivolol guide →How Each Drug Works
Citalopram
The mechanism of action of citalopram is unclear, but is presumed to be related to potentiation of serotonergic activity in the central nervous system (CNS) resulting from its inhibition of CNS neuronal reuptake of serotonin (5-HT).
Nebivolol
The mechanism of action of the antihypertensive response of nebivolol has not been definitively established. Possible factors that may be involved include: decreased heart rate, decreased myocardial contractility, diminution of tonic sympathetic outflow to the periphery from cerebral vasomotor centers, suppression of renin activity and vasodilation and decreased peripheral vascular resistance.
Approved Uses (Indications)
Citalopram
Citalopram is indicated for the treatment of major depressive disorder (MDD) in adults [see Clinical Studies ] . Citalopram is a selective serotonin reuptake inhibitor (SSRI) indicated for the treatment of major depressive disorder (MDD) in adults .
Nebivolol
Nebivolol Tablets are a beta-adrenergic blocking agent indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. 1.1 Hypertension Nebivolol tablets are indicated for the treatment of hypertension, to lower blood pressure [see Clinical Studies ] . Nebivolol tablets may be used alone or in combination with other antihypertensive agents [see Drug Interactions ] . Lowering blood pressure reduces the risk of fata…
Side Effects
Citalopram
Nebivolol
Cost Comparison
Citalopram
$4–$25/month
As a widely available generic, Citalopram is very affordable. Using discount cards like GoodRx can further reduce the cost to just a few dollars per month.
Nebivolol
$200–$500/month
Since Nebivolol does not have a generic version, look for manufacturer coupons or patient assistance programs to significantly reduce the cost. Discount cards may also offer some savings.
Drug Interaction: Moderate
Citalopram is a weak inhibitor of CYP2D6, which is the primary enzyme responsible for nebivolol's metabolism. This interaction can lead to increased plasma concentrations of nebivolol, potentially enhancing its beta-blocking effects such as bradycardia, hypotension, and heart block.
Mechanism: Citalopram weakly inhibits cytochrome P450 2D6 (CYP2D6). Nebivolol is primarily metabolized by CYP2D6, so inhibition of this enzyme can reduce nebivolol clearance, increasing its systemic exposure.
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Medical Disclaimer
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