Combining Clopidogrel and Diclofenac Sodium is a major interaction and should generally be avoided without close medical supervision.
Combining diclofenac with clopidogrel significantly increases your risk of bleeding, especially from the stomach or intestines. This combination should generally be avoided.
Mechanism: Diclofenac, a non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis which protects the gastrointestinal lining and also impairs platelet aggregation. Clopidogrel is an antiplatelet agent that irreversibly inhibits the P2Y12 ADP receptor on platelets, preventing platelet activation and aggregation. The concurrent use of these agents results in additive antiplatelet effects and increased gastrointestinal mucosal damage, leading to a synergistic increase in bleeding risk.
Clopidogrel vs. Diclofenac Sodium
Compare Clopidogrel and Diclofenac Sodium: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Clopidogrel
Clopidogrel
Antiplatelet Agents
RxDrug B
Diclofenac Sodium
Diclofenac Sodium
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Clopidogrel | Diclofenac Sodium |
|---|---|---|
| Drug Class | Antiplatelet Agents | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $10–$30/month | $10-$30/month |
Clopidogrel Overview
CLOPIDOGREL (brand name: Clopidogrel) is a Antiplatelet Agents. 1 INDICATIONS & USAGE Clopidogrel is a P2Y 12 platelet inhibitor indicated for: • Acute coronary syndrome - For patients with non-ST-segment elevation ACS (unstable angina [UA]/non-ST-elevation myocardial infarction [NSTEMI]), clopidogrel has been shown to reduce the rate of myocardial infarction…
Full Clopidogrel guide →Diclofenac Sodium Overview
DICLOFENAC SODIUM (brand name: Diclofenac Sodium) is a NSAIDs. 1 INDICATIONS AND USAGE Diclofenac sodium topical solution, USP is indicated for the treatment of signs and symptoms of osteoarthritis of the knee(s) (1). Diclofenac sodium topical solution is a nonsteroidal anti-inflammatory drug indicated for the treatment of signs and symptoms of osteoarthritis…
Full Diclofenac Sodium guide →How Each Drug Works
Clopidogrel
Clopidogrel is an inhibitor of platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y 12 class of ADP receptors on platelets.
Diclofenac Sodium
Diclofenac has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of diclofenac sodium, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Diclofenac is a potent inhibitor of prostaglandin synthesis in vitro. Diclofenac concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in induc…
Approved Uses (Indications)
Clopidogrel
Clopidogrel is a P2Y 12 platelet inhibitor indicated for:
- Acute coronary syndrome - For patients with non-ST-segment elevation ACS (unstable angina [UA]/non-ST-elevation myocardial infarction [NSTEMI]), clopidogrel has been shown to reduce the rate of myocardial infarction (MI) and stroke. - For patients with ST-elevation myocardial infarction (STEMI), clopidogrel has been shown to reduce the rate of MI and stroke.
- Recent MI, recent stroke, or established peripheral arterial disease. Clopidogrel has been shown to reduce the rate of MI and stroke. ( 1.2…
Diclofenac Sodium
Diclofenac sodium topical solution, USP is indicated for the treatment of signs and symptoms of osteoarthritis of the knee(s) . Diclofenac sodium topical solution is a nonsteroidal anti-inflammatory drug indicated for the treatment of signs and symptoms of osteoarthritis of the knee(s).
Side Effects
Clopidogrel
Diclofenac Sodium
Cost Comparison
Clopidogrel
$10–$30/month
Clopidogrel is available as a low-cost generic. Using discount cards like GoodRx can further reduce the price, often bringing it down to under $10 per month.
Diclofenac Sodium
$10-$30/month
Diclofenac sodium is widely available as a low-cost generic. Patients can often find significant savings by using discount cards or pharmacy loyalty programs.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.