Combining Cyclobenzaprine Hydrochloride and Methadone is a major interaction and should generally be avoided without close medical supervision.
Patients may experience increased sedation, dizziness, confusion, and psychomotor impairment. The most serious clinical effects include profound respiratory depression, which can be life-threatening, and hypotension. Impaired motor function and cognitive ability can also increase the risk of falls and accidents.
Mechanism: Methadone is a potent opioid agonist that produces central nervous system (CNS) depression by binding to mu-opioid receptors. Cyclobenzaprine hydrochloride is a centrally acting skeletal muscle relaxant that also causes CNS depression, likely through its anticholinergic effects and action on the brainstem. The co-administration of these two agents results in an additive depressant effect on the CNS.
Cyclobenzaprine Hydrochloride vs. Methadone
Compare Cyclobenzaprine Hydrochloride and Methadone: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Cyclobenzaprine Hydrochloride
Cyclobenzaprine Hydrochloride
Skeletal Muscle Relaxants
RxDrug B
Methadone
Methadone Hydrochloride
Opioid Analgesics
RxQuick Comparison
| Category | Cyclobenzaprine Hydrochloride | Methadone |
|---|---|---|
| Drug Class | Skeletal Muscle Relaxants | Opioid Analgesics |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $10–$30/month | $15–$60/month |
Cyclobenzaprine Hydrochloride Overview
Cyclobenzaprine Hydrochloride is a muscle relaxant medication used to relieve muscle spasms caused by acute, painful muscle and bone conditions. It works by helping to relax the muscles, which can reduce pain, tenderness, and improve movement when used with rest and physical therapy. This medication is typically used for short periods to help you recover from these types of injuries.
Full Cyclobenzaprine Hydrochloride guide →Methadone Overview
METHADONE (brand name: Methadone Hydrochloride) is a Opioid Analgesics. 1 INDICATIONS AND USAGE Methadone hydrochloride tablets is indicated for the: Management of severe and persistent pain that requires an opioid analgesic and that cannot be adequately treated with alternative options, including immediate-release opioids. Limitations of Use Because of the risks of…
Full Methadone guide →How Each Drug Works
Methadone
Methadone hydrochloride is a mu-agonist; a synthetic opioid with multiple actions qualitatively similar to those of morphine, the most prominent of which involves the central nervous system and organs composed of smooth muscle. The principal therapeutic uses for methadone are for analgesia and for detoxification or maintenance in opioid addiction. The methadone withdrawal syndrome, although qualitatively similar to that of morphine, differs in that the onset is slower, t…
Approved Uses (Indications)
Cyclobenzaprine Hydrochloride
INDICATIONS AND USAGE Cyclobenzaprine hydrochloride tablets are indicated as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions. Improvement is manifested by relief of muscle spasm and its associated signs and symptoms, namely, pain, tenderness, limitation of motion, and restriction in activities of daily living. Cyclobenzaprine hydrochloride tablets should be used only for short periods (up to two or three weeks) because adequate evidence of effectiveness for more prolonged use is not available and because muscle spasm …
Methadone
Methadone hydrochloride tablets is indicated for the: Management of severe and persistent pain that requires an opioid analgesic and that cannot be adequately treated with alternative options, including immediate-release opioids. Limitations of Use Because of the risks of addiction, abuse, misuse, overdose, and death, which can occur at any dosage or duration and persist over the course of therapy [see WARNINGS AND PRECAUTIONS ], reserve opioid analgesics, including methadone hydrochloride tablets, for use in patients for whom alternative analgesic treatment opti…
Side Effects
Cyclobenzaprine Hydrochloride
Methadone
Cost Comparison
Cyclobenzaprine Hydrochloride
$10–$30/month
As a widely available generic, Cyclobenzaprine Hydrochloride is very affordable, especially with discount cards like GoodRx. Always compare prices at different pharmacies and consider using a coupon.
Methadone
$15–$60/month
Generic methadone is very affordable, especially with discount cards like GoodRx. Many pharmacies offer low-cost programs for this medication.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.