Combining Dabigatran Etexilate Mesylate and Ibuprofen is a major interaction and should generally be avoided without close medical supervision.
Combining ibuprofen with dabigatran significantly increases your risk of serious bleeding, especially from the stomach or intestines. This combination should generally be avoided.
Mechanism: Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase (COX) enzymes, leading to reduced prostaglandin synthesis and impaired platelet aggregation. Dabigatran is a direct thrombin inhibitor that prevents the formation of blood clots. The concurrent use of these agents results in an additive antiplatelet and anticoagulant effect, significantly increasing the risk of bleeding.
Dabigatran Etexilate Mesylate vs. Ibuprofen
Compare Dabigatran Etexilate Mesylate and Ibuprofen: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Dabigatran Etexilate Mesylate
Pradaxa
Anticoagulants
RxDrug B
Ibuprofen
good neighbor pharmacy ibuprofen
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Dabigatran Etexilate Mesylate | Ibuprofen |
|---|---|---|
| Drug Class | Anticoagulants | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $400–$600/month | $4-$15/month |
Dabigatran Etexilate Mesylate Overview
Dabigatran (Pradaxa) is a medication that helps prevent blood clots from forming in your body. It works by directly blocking a substance called thrombin, which is essential for blood clotting. This medicine is primarily used to reduce the risk of stroke in people with a type of irregular heartbeat called atrial fibrillation, and to treat or prevent deep vein clots (DVT) and lung clots (PE) in cert...
Full Dabigatran Etexilate Mesylate guide →Ibuprofen Overview
IBUPROFEN (brand name: good neighbor pharmacy ibuprofen) is a NSAIDs. Uses • temporarily relieves minor aches and pains due to: • headache • muscular aches • minor pain of arthritis • toothache • backache • the common cold • menstrual cramps • temporarily reduces fever
Full Ibuprofen guide →How Each Drug Works
Dabigatran Etexilate Mesylate
Dabigatran and its acyl glucuronides are competitive, direct thrombin inhibitors. Because thrombin (serine protease) enables the conversion of fibrinogen into fibrin during the coagulation cascade, its inhibition prevents the development of a thrombus. Both free and clot-bound thrombin, and thrombin-induced platelet aggregation are inhibited by the active moieties.
Approved Uses (Indications)
Dabigatran Etexilate Mesylate
Capsules is a direct thrombin inhibitor indicated: To reduce the risk of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation For the treatment of deep venous thrombosis (DVT) and pulmonary embolism (PE) in adult patients who have been treated with a parenteral anticoagulant for 5-10 days To reduce the risk of recurrence of DVT and PE in adult patients who have been previously treated For the prophylaxis of DVT and PE in adult patients who have undergone hip replacement surgery For the treatment of …
Ibuprofen
Uses
- temporarily relieves minor aches and pains due to:
- headache
- muscular aches
- minor pain of arthritis
- toothache
- backache
- the common cold
- menstrual cramps
- temporarily reduces fever
Side Effects
Dabigatran Etexilate Mesylate
Cost Comparison
Dabigatran Etexilate Mesylate
$400–$600/month
As Pradaxa is a brand-name medication without a generic, manufacturer coupons or patient assistance programs are often the best ways to reduce out-of-pocket costs.
Ibuprofen
$4-$15/month
Ibuprofen is widely available as an inexpensive generic, even without insurance. Discount cards can further reduce the cost at many pharmacies.
Compare prices for Dabigatran Etexilate Mesylate and Ibuprofen
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.