Combining Dabigatran Etexilate Mesylate and Naproxen is a major interaction and should generally be avoided without close medical supervision.
Combining naproxen, an NSAID, with dabigatran, an anticoagulant, significantly increases the risk of serious bleeding, including internal bleeding. This combination should generally be avoided.
Mechanism: Naproxen inhibits cyclooxygenase (COX-1 and COX-2), leading to reduced prostaglandin synthesis, which impairs gastric mucosal protection and inhibits platelet aggregation. Dabigatran directly inhibits thrombin, preventing clot formation. The concurrent use of these agents results in additive antiplatelet and anticoagulant effects, severely compromising hemostasis.
Dabigatran Etexilate Mesylate vs. Naproxen
Compare Dabigatran Etexilate Mesylate and Naproxen: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Dabigatran Etexilate Mesylate
Pradaxa
Anticoagulants
RxDrug B
Naproxen
Naproxen
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Dabigatran Etexilate Mesylate | Naproxen |
|---|---|---|
| Drug Class | Anticoagulants | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $400–$600/month | $4–$25/month |
Dabigatran Etexilate Mesylate Overview
Dabigatran (Pradaxa) is a medication that helps prevent blood clots from forming in your body. It works by directly blocking a substance called thrombin, which is essential for blood clotting. This medicine is primarily used to reduce the risk of stroke in people with a type of irregular heartbeat called atrial fibrillation, and to treat or prevent deep vein clots (DVT) and lung clots (PE) in cert...
Full Dabigatran Etexilate Mesylate guide →Naproxen Overview
NAPROXEN (brand name: Naproxen) is a NSAIDs. 1 INDICATIONS & USAGE Naproxen delayed-release tablets are indicated for: the relief of the signs and symptoms of: rheumatoid arthritis osteoarthritis ankylosing spondylitis Polyarticular Juvenile Idiopathic Arthritis Naproxen delayed-release tablets are non-steroidal anti-inflammatory drugs…
Full Naproxen guide →How Each Drug Works
Dabigatran Etexilate Mesylate
Dabigatran and its acyl glucuronides are competitive, direct thrombin inhibitors. Because thrombin (serine protease) enables the conversion of fibrinogen into fibrin during the coagulation cascade, its inhibition prevents the development of a thrombus. Both free and clot-bound thrombin, and thrombin-induced platelet aggregation are inhibited by the active moieties.
Naproxen
Naproxen has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of naproxen, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Naproxen is a potent inhibitor of prostaglandin synthesis in vitro. Naproxen concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in ani…
Approved Uses (Indications)
Dabigatran Etexilate Mesylate
Capsules is a direct thrombin inhibitor indicated: To reduce the risk of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation For the treatment of deep venous thrombosis (DVT) and pulmonary embolism (PE) in adult patients who have been treated with a parenteral anticoagulant for 5-10 days To reduce the risk of recurrence of DVT and PE in adult patients who have been previously treated For the prophylaxis of DVT and PE in adult patients who have undergone hip replacement surgery For the treatment of …
Naproxen
Naproxen delayed-release tablets are indicated for: the relief of the signs and symptoms of: rheumatoid arthritis osteoarthritis ankylosing spondylitis Polyarticular Juvenile Idiopathic Arthritis Naproxen delayed-release tablets are non-steroidal anti-inflammatory drugs indicated for: the relief of the signs and symptoms of: rheumatoid arthritis osteoarthritis ankylosing spondylitis polyarticular juvenile idiopathic arthritis
Side Effects
Dabigatran Etexilate Mesylate
Naproxen
Cost Comparison
Dabigatran Etexilate Mesylate
$400–$600/month
As Pradaxa is a brand-name medication without a generic, manufacturer coupons or patient assistance programs are often the best ways to reduce out-of-pocket costs.
Naproxen
$4–$25/month
Naproxen is widely available as an affordable generic. Using discount cards like GoodRx can further reduce the cost, often bringing it to under $10 per month.
Compare prices for Dabigatran Etexilate Mesylate and Naproxen
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.